Two experiments were conducted to determine whether vowel familiarity affects automatic and conscious vowel discrimination. Familiar (Finnish) and unfamiliar (Komi) vowels were presented to Finnish subjects. The good representatives of Finnish and Komi mid vowels were grouped into three pairs: front /e- epsilon /, central /ø-oe/, and back /o-o/. The acoustic difference for /e- epsilon / and /o-o/ was smaller than that for /ø-oe/. For /e- epsilon /, the Komi vowel / epsilon / was at the boundary between the Finnish /e/ and /ae/. The stimuli were presented in an oddball paradigm. In three different blocks, each Komi vowel in turn served as the standard (probability 0.86) and the corresponding Finnish vowel as the deviant stimulus (probability 0.14), and vice versa. In Experiment 1, subjects were instructed to press a button as soon as they detected a deviant stimulus. In Experiment 2, event-related potentials (ERPs) were recorded to these stimuli in order to use the mismatch negativity (MMN) as an index of the perceptual distance between the members of each vowel pair, while subjects did not attend to the stimuli. There were similar effects of the acoustic distance within a vowel pair for both the reaction time (RT) and the MMN amplitude; the RT decreased and the MMN amplitude increased when the acoustic difference between the stimuli increased. However, the RT was longer when the Komi / epsilon / was the standard and the Finnish /e/ was the deviant than vice versa. No such pattern was found for the MMN. Thus, the phonemic status of the standard stimulus seems to play a role at the attentive but not at the pre-attentive level.
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Sci Rep
January 2025
Laboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, Pará, 66075-110, Brazil.
Plastic poses a significant environmental impact due to its chemical resilience, leading to prolonged and degradation times and resulting in widespread adverse effects on global flora and fauna. Cutinases are essential enzymes in the biodegradation process of synthetic polymers like polyethylene terephthalate (PET), which recognized organisms can break down. Here, we used molecular dynamics and binding free energy calculations to explore the interaction of nine synthetic polymers, including PET, with Cutinase from Fusarium oxysporum (FoCut).
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March 2025
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo, Kyoto 615-8510, Japan.
κ-Carrageenan hydrogels have been prepared at very high concentrations beyond the previous limit of conventional κ-carrageenan hydrogels. By dissolving κ-carrageenan using subcritical water at 150 °C, homogeneous translucent hydrogels have been obtained from 15 wt% to 40 wt%. The high-concentration hydrogels have exceptionally high Young's modulus (E) ranging 10-10 Pa and exhibit an unknown concentration (c)-dependence of E ∝ c.
View Article and Find Full Text PDFFood Chem
January 2025
School of Food Science and Engineering, and Natural Food Macromolecule Research Center, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021, China. Electronic address:
The synergistic effects of allicin nanoemulsion (AcN) and ε-polylysine (ε-PL) against Escherichia coli were investigated in this study. The combination of AcN and ε-PL synergistically inhibited the planktonic growth of E. coli, with a low fractional inhibitory concentration index of 0.
View Article and Find Full Text PDFLangmuir
January 2025
College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Nanocomposites of epoxy with FeO featuring dynamic disulfide bonds were fabricated. To facilitate the dispersion of FeO nanoparticles, we synthesized poly(ε-caprolactone)-grafted FeO nanoparticles, which were then incorporated into epoxy to generate robust interfacial interactions between epoxy and the inorganic nanoparticles. Through this approach, a fine dispersion of the inorganic nanoparticles in the epoxy matrix was successfully obtained.
View Article and Find Full Text PDFInt J Pharm
January 2025
Nanostructure and Biomimetic Lab, Department of Nanotechnology, University of Kashmir, Hazratbal, Srinagar 190006, Jammu and Kashmir, India. Electronic address:
The second most prevalent cause of mortality among women is breast cancer, and paclitaxel (PTX) is an effective drug for its treatment. The present work aims to develop patch-based poly(ε-caprolactone) (PCL) nanofibers incorporating PTX as a localized and sustained drug delivery system. The co-deposition of poly(vinyl alcohol) (PVA) fibers during electrospinning was allowed to improve water absorption by the scaffold, which in turn facilitated the release of drug molecules.
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