AI Article Synopsis
- The study investigated the T cell response to a specific variant of the acetylcholine receptor (AChR alpha) in blood samples from myasthenia gravis (MG) patients and healthy individuals.
- Five late-onset MG patients with thymoma showed T cells that reacted to the P3A region of the AChR alpha, while no healthy donors displayed this response.
- These autoreactive T cells may play a role in the disease process for certain MG patients.
Article Abstract
In vitro T cell proliferative response to an alternative splicing variant of acetylcholine receptor alpha subunit (AChR alpha) with the P3A exon-encoded region was examined in peripheral blood samples from 28 myasthenia gravis (MG) patients and 14 healthy donors using recombinant fragments and synthetic peptides. T cells responsive to the P3A region-specific sequences were detected in five MG patients, all of whom were late-onset disease with thymoma, but in none of healthy donors. These autoreactive T cells may be involved in the pathogenic process in a subset of MG patients.
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| http://dx.doi.org/10.1016/s0165-5728(03)00078-x | DOI Listing |
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