In order to acquire freezing model of the cryopretective solution (NaCl-propylene glycol-water ternary system) for platelet, the melting points (T(f)) of this cryopretective solutions with different solute concentration and different ratio of PG mass to NaCl mass were measured by using a differential scanning calorimeter (DSC), and these experimental data were fitting by computer. An empirical equation was derived which characterized the Tf as a function of the solute concentration and the ratio of PG mass to NaCl mass inside this solution. It was concluded that the equilibrium freezing model for human platelets in this system could be used to instruct platelet cryopreserving techniques.
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Heliyon
January 2025
Operational Research Center in Healthcare, Near East University, TRNC Mersin 10, Nicosia, 99138, Turkey.
Efficient thermal management is crucial for optimizing the performance and longevity of automotive engines, particularly as environmental regulations become more stringent and consumer demand for fuel efficiency increases. This paper investigates the energy and exergy performance of a wavy fin-and-tube radiator employing novel ternary nanofluids (TNFs) for enhanced automotive cooling. A theoretical comparative analysis was performed on four distinct ethylene glycol-water solution-based TNF configurations.
View Article and Find Full Text PDFACS Omega
January 2025
Department of Chemistry, DAV College, Sector-10, Chandigarh 160011,India.
This study investigates solute-solvent interactions in ternary systems consisting of lithium trifluoromethanesulfonate (LiOTf) as the solute and tetraethylene glycol dimethyl ether (TEGDME) and 1,2-dimethoxyethane (DME) as solvents over a range of temperatures (293.15-313.15 K).
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
Institute of Physical and Theoretical Chemistry, University of Regensburg D-93053 Regensburg, Germany. Electronic address:
Hypothesis: Due to its huge polar headgroup, octaoxyethylene octyl ether carboxylic acid (CECHCOOH = Akypo LF2™) is supposed not to be able to change its curvature sufficiently to form bicontinuous microemulsions. Instead, upon adding an oil to the binary water - surfactant system, excess oil could be squeezed out or a biliquid foam could form.
Experiments: An auto-dilution setup was used to record small-angle X-ray scattering data along six dilution lines in the newly established phase diagram of the ternary system 2-ethylhexanol - CECHCOOH - water.
RSC Chem Biol
January 2025
School of Chemistry, The University of Sydney Sydney NSW 2006 Australia
Targeted protein degraders, in the form of proteolysis targeting chimaeras (PROTACs) and molecular glues, leverage the ubiquitin-proteasome system to catalytically degrade specific target proteins of interest. Because such molecules can be extremely potent, they have attracted considerable attention as a therapeutic modality in recent years. However, while targeted degraders have great potential, they are likely to face many of the same challenges as more traditional small molecules when it comes to their development as therapeutics.
View Article and Find Full Text PDFSurface active ionic liquids (SAILs), offer potential advantages for pharmaceutical applications. Given the low permeability of gabapentin, an antiepileptic drug, in the gastrointestinal tract as classified by the Biopharmaceutics Classification Systems (BCS), understanding the micellization behavior of SAILs is essential for developing effective drug delivery systems to improve gabapentin bioavailability. This study explores the micellization and thermophysical behavior of SAILs (2-hydroxyethyl)ammonium laurate [2-HEA][Lau], bis(2-hydroxyethyl)ammonium laurate [BHEA][Lau], and tris(2-hydroxyethyl)ammonium laurate [THEA][Lau] in the presence of aqueous gabapentin solution at varied temperatures through COSMO analysis, electrical conductivity and surface tension measurements.
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