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Objective Sleep Function is Associated with Hippocampal Subfield Volumes in Community-Dwelling Adults.
J Integr Neurosci
August 2024
1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Background: Sleep patterns often shift as people age, a phenomenon frequently associated with the onset of neurodegenerative conditions. Additionally, distinct alterations occur in brain structure as individuals grow older, particularly within the hippocampus, a region known for its role in cognition and sleep regulation. Yet, how exactly do changes in sleep relate to specific subfields within the hippocampus is still unclear.
View Article and Find Full Text PDFCognitive reserve, cortisol, and Alzheimer's disease biomarkers: A memory clinic study.
Alzheimers Dement
July 2024
Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.
Introduction: Cognitive reserve might mitigate the risk of Alzheimer's dementia among memory clinic patients. No study has examined the potential modifying role of stress on this relation.
Methods: We examined cross-sectional associations of the cognitive reserve index (CRI; education, occupational complexity, physical and leisure activities, and social health) with cognitive performance and AD-related biomarkers among 113 memory clinic patients.
Night-to-night variability in sleep and amyloid beta burden in normal aging.
Alzheimers Dement (Amst)
September 2023
INCIA, EPHE, Université PSL Univ Bordeaux CNRS Bordeaux France.
Article Synopsis
- Alzheimer's disease can mess with sleep and cause a buildup of a harmful substance in the brain called amyloid beta.
- The study measured sleep patterns using a special device and compared them with brain scans to see if they could help identify early signs of amyloid buildup.
- It found that people with more sleep interruptions had more amyloid in certain parts of their brains, suggesting that sleep issues could help detect early Alzheimer's.
Connectivity between Gut Microbiota and Terminal Awakenings in Alzheimer's Disease.
Curr Alzheimer Res
July 2023
Department of Physiology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
Memory is empirically described as a brain function that connects the past to the present. This reductionist approach has focused on memory function within neurons and synapses, leading to an understanding that memory loss in dementia is caused by irreversible neuronal damage. However, recent palliative case reports and the Human Connectome Project have challenged the "irreversible" paradigm by indicating that some demented patients are able to retrieve supposed 'lost' memories and cognitive functions near death.
View Article and Find Full Text PDFHome EEG sleep assessment shows reduced slow-wave sleep in mild-moderate Alzheimer's disease.
Alzheimers Dement (N Y)
August 2022
Introduction: Sleep disturbances are common in Alzheimer's disease (AD), with estimates of prevalence as high as 65%. Recent work suggests that specific sleep stages, such as slow-wave sleep (SWS) and rapid eye movement (REM), may directly impact AD pathophysiology. A major limitation to sleep staging is the requirement for clinical polysomnography (PSG), which is often not well tolerated in patients with dementia.
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