By using specific key words, clinicians can use an Internet database service to identify federally funded grant and scholarship opportunities--opportunities more frequently sought by basic scientists. The authors hypothesized that such an Internet service could be used as a research tool to examine and compare the clinical research preferences of potential medical and bioscience investigators. The authors selected 577 key words from an online key word thesaurus used by both the federal government and ScienceWise.com. These key words formed a survey instrument to measure the research interests of 40 family medicine academic faculty members of a college of osteopathic medicine. The findings were compared to a survey by ScienceWise.com of its 102,578 subscribers and to previous surveys of nonacademic clinicians. Results indicate an efficient means of determining research interests as well as a method of alerting academic clinicians/nonclinicians and basic scientists to current funding opportunities.
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J Endocrinol Invest
January 2025
Department of Internal Medicine, Maastricht University Medical Center, Maastricht, 6229ER, the Netherlands.
Purpose: Elevated methylglyoxal (MGO) levels and altered immune cell responses are observed in diabetes. MGO is thought to modulate immune cell activation. The current study investigated whether fasting or post-glucose-load plasma MGO concentrations are associated with circulating immune cell counts and activation in a large cohort study.
View Article and Find Full Text PDFPaediatr Drugs
January 2025
Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
Despite significant global reductions in cases of pneumonia during the last 3 decades, pneumonia remains the leading cause of post-neonatal mortality in children aged <5 years. Beyond the immediate disease burden it imposes, pneumonia contributes to long-term morbidity, including lung function deficits and bronchiectasis. Viruses are the most common cause of childhood pneumonia, but bacteria also play a crucial role.
View Article and Find Full Text PDFSci Rep
January 2025
Chulalongkorn Autism Research and Innovation Center of Excellence (Chula ACE), Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, 154 Soi Chula 12, Rama 1 Road, Wangmai, Pathumwan, Bangkok, 10330, Thailand.
Bisphenol A (BPA), an endocrine-disrupting chemical, is increasingly linked to the pathogenesis of autism spectrum disorder (ASD). This study investigates the effects of prenatal BPA exposure on neural stem cells (NSCs) from the hippocampi of rat offspring, a brain region critical for neurodevelopment and implicated in ASD. Pregnant rats were administered with BPA or vehicle control once daily via oral gavage from gestational day 1 until parturition.
View Article and Find Full Text PDFMikrochim Acta
January 2025
Centro de Investigación en Biotecnología Aplicada del Instituto Politécnico Nacional, Ex-Hacienda San Juan Molino Carretera Estatal Tecuexcomac-Tepetitla Km 1.5, 90700, Tlaxcala, México.
Foodborne diseases are a significant cause of morbidity (600 million cases) and mortality (420,000 deaths) worldwide every year and are mainly associated with pathogens. Besides the direct effects on human health, they have relevant concerns related to financial, logistics, and infrastructure for the food and medical industries. The standard pathogen identification techniques usually require a sample enrichment step, plating, isolation, and biochemical tests.
View Article and Find Full Text PDFDev Cogn Neurosci
December 2024
Thompson Institute, University of the Sunshine Coast, Birtinya, QLD, Australia. Electronic address:
This temporally rich, longitudinal study of early adolescents (N = 88, 277 datasets, 12-13 years) investigated the relationship between bilateral subcortical grey matter volume (GMV) in the hippocampus, amygdala, accumbens-area, caudate, putamen and pallidum with self-reported mental wellbeing at four timepoints, across 12 months. Generalised Estimating Equations (GEE) revealed (1) higher 'total wellbeing' was associated with smaller left caudate and larger left accumbens-area; (2) higher eudaimonic wellbeing was associated with smaller left caudate and larger right caudate; and (3) higher hedonic wellbeing was associated with larger left accumbens-area. Further analyses and plots highlighted different associations between GMV and wellbeing for adolescents who consistently experienced 'moderate-to-flourishing' wellbeing (n = 63, 201 datasets), compared with those who experienced 'languishing' wellbeing at any timepoint (n = 25, 76 datasets).
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