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Nuclear translocation of the membrane oxoeicosanoid/androgen receptor, OXER1: Possible mechanisms involved.
Mol Cell Endocrinol
December 2024
Laboratory of Experimental Endocrinology, School of Medicine, University of Crete, Voutes Campus, 70013, Heraklion, Crete, Greece. Electronic address:
OXER1, the receptor for the arachidonic acid metabolite 5-οxo-eicosatetraenoic acid (5-oxo-ETE), has been reported to also bind and mediate the membrane-initiated actions of androgens. Indeed, androgens antagonize the 5-oxo-ETE effects through OXER1, affecting a number of signaling pathways and inhibiting cancer cell proliferation and migration. OXER1, being a GPCR, was classically described to be localized in the plasma membrane.
View Article and Find Full Text PDFFABP5-binding lipids regulate autophagy in differentiated SH-SY5Y cells.
PLoS One
June 2024
Biomolecular Sciences Ph.D. Program, Boise State University, Boise, ID, United States of America.
The motor features of Parkinson's disease result from loss of dopaminergic neurons in the substantia nigra with autophagy dysfunction being closely linked to this disease. While a large body of work focusing on protein effectors of autophagy has been reported, regulation of autophagy by lipids has garnered far less attention. Therefore, we sought to identify endogenous lipid molecules that act as signaling mediators of autophagy in differentiated SH-SY5Y cells, a commonly used dopaminergic neuron-like cell model.
View Article and Find Full Text PDF5-Oxo-ETE/OXER1: A Link between Tumor Cells and Macrophages Leading to Regulation of Migration.
Molecules
December 2023
Laboratory of Experimental Endocrinology, School of Medicine, University of Crete, 71500 Heraklion, Greece.
Chronic inflammation is an important factor in the development of cancer. Macrophages found in tumors, known as tumor associated macrophages (TAMs), are key players in this process, promoting tumor growth through humoral and cellular mechanisms. 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), an arachidonic acid metabolite, has been described to possess a potent chemoattractant activity for human white blood cells (WBCs).
View Article and Find Full Text PDFMining the ZINC database of natural products for specific, testosterone-like, OXER1 antagonists.
Steroids
November 2023
Laboratory of Experimental Endocrinology, University of Crete, School of Medicine, Heraklion, Greece. Electronic address:
OXER1, the receptor for the oxidized arachidonic acid metabolite 5-oxo-ETE has been reported to play a significant role in inflammatory responses, being responsible for leucocyte chemotactic responses. Recently, we have identified OXER1 (GPR170) as a membrane receptor for androgens in prostate and breast cancer cells. Testosterone action via OXER1 induces specific Ca release from intracellular organelles, modifies polymerized actin distribution induces apoptosis and decreases cancer cell migration.
View Article and Find Full Text PDFLipid Mediators and Cytokines/Chemokines Display Differential Profiles in Severe versus Mild/Moderate COVID-19 Patients.
Int J Mol Sci
August 2023
Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Host immune responses play a key role in COVID-19 pathogenesis. The underlying phenomena are orchestrated by signaling molecules such as cytokines/chemokines and lipid mediators. These immune molecules, including anti-SARS-CoV-2 antibodies, interact with immune cells and regulate host responses, contributing to inflammation that drives the disease.
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