The Leyton obsessional inventory - child version in Greek adolescents: standardization in a national school-based survey and two-year follow-up.

Objective: The aims of this study were a) to standardize the survey form of the Leyton Obsessional Inventory - Child Version (Leyton-CV) in Greece, and estimate its sensitivity and specificity, and b) to assess high-risk factors for the development of adolescent obsessive-compulsive disorder (OCD) within a two year period.

Method: The Leyton-CV was administered to a national, representative, school-based population of 2552 Greek adolescents. Adolescents with a wide range of Leyton-CV scores were interviewed with the SADS-LA to determine the sensitivity and specificity of the instrument. Adolescents with high Leyton scores but no OCD diagnosis, and those with obsessive-compulsive symptoms (OCS), were re-interviewed after two years with the SADS-LA. Family history data on OCD and other mental illness were obtained through the Family Informant Schedule at follow-up.

Results: Using a cut-off point of 35 for the total score, the sensitivity of the Leyton-CV was 79.4 % and the specificity 72.6 %. High Leyton-CV scores and a positive family history for OCD/OCS appeared to constitute high risk factors for later OCD/OCS in adolescents.