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Background Malaria remains one of the most significant public health challenges, particularly in pediatric populations in developing countries. Rapid diagnostic tests (RDTs) have been widely adopted due to their ease of use and quick results, but their diagnostic accuracy, compared to microscopy, the gold standard, remains a topic of interest. Early and accurate detection of malaria is crucial in reducing complications and mortality in children, who are especially vulnerable to delayed or inaccurate diagnoses.
View Article and Find Full Text PDFPost-discharge malaria chemoprevention in children admitted with severe anaemia in malaria-endemic settings in Africa: a systematic review and individual patient data meta-analysis of randomised controlled trials.
Lancet Glob Health
January 2024
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya. Electronic address:
Background: Severe anaemia is associated with high in-hospital mortality among young children. In malaria-endemic areas, surviving children also have an increased risk of mortality or readmission after hospital discharge. We conducted a systematic review and individual patient data meta-analysis to determine the efficacy of monthly post-discharge malaria chemoprevention in children recovering from severe anaemia.
View Article and Find Full Text PDFGenus : A Hidden Treasure Trove of Structurally Unique and Diversely Bioactive Secondary Metabolites.
Mar Drugs
September 2023
School of Medicine, Shanghai University, 99 Shangda Road, Bao Shan District, Shanghai 200444, China.
Marine soft corals are prolific sources of various natural products that have served as a wealthy reservoir of diverse chemical scaffolds with potential as new drug leads. The genus contains almost 100 species but only a small proportion of them has been chemically investigated, which calls for more attentions from global researchers. In the current work, 175 secondary metabolites have been discussed, drawing from published data spanning almost five decades, up to July 2023.
View Article and Find Full Text PDFPET-PCR reveals low parasitaemia and submicroscopic malarial infections in Honduran Moskitia.
Malar J
March 2023
Microbiology Research Institute, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.
Background: Malaria remains a main parasitic disease of humans. Although the largest number of cases is reported in the African region, there are still endemic foci in the Americas. Central America reported 36,000 malaria cases in 2020, which represents 5.
View Article and Find Full Text PDFFolic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Cochrane Database Syst Rev
February 2022
National Center on Birth Defects and Developmental Disabilities, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
Background: Description of the condition Malaria, an infectious disease transmitted by the bite of female mosquitoes from several Anopheles species, occurs in 87 countries with ongoing transmission (WHO 2020). The World Health Organization (WHO) estimated that, in 2019, approximately 229 million cases of malaria occurred worldwide, with 94% occurring in the WHO's African region (WHO 2020). Of these malaria cases, an estimated 409,000 deaths occurred globally, with 67% occurring in children under five years of age (WHO 2020).
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