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Impact of chronic obstructive pulmonary disease in patients with atrial fibrillation: an analysis from the GLORIA-AF registry.
Europace
December 2023
Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK.
Article Synopsis
- The study examined the relationship between chronic obstructive pulmonary disease (COPD) and atrial fibrillation (AF) using data from the global GLORIA-AF registry, focusing on how COPD affects treatment and outcomes.
- Out of 36,263 patients, 6.2% had COPD, with varying prevalence in different regions; factors like age, gender, and smoking were linked to COPD presence.
- COPD patients experienced different medication patterns and significantly worse health outcomes, including higher risks of death, major adverse cardiovascular events (MACEs), and major bleeding compared to patients without COPD.
Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock and Hyperkalaemia Syndrome Involving Digoxin Toxicity: A Case Report.
Heart Int
June 2023
Department of Internal Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Bradycardia, renal failure, atrioventricular nodal blockade, shock and hyperkalemia (BRASH) syndrome is named after the pentad of symptoms experienced by patients with this clinical entity, and is propagated via a synergistic mechanism. Herein, we describe a case of an 81-year-old male who presented with bradycardia, dyspnoea on exertion, and confusion. He was also initially found to be in cardiogenic shock.
View Article and Find Full Text PDFDrug-induced cognitive impairment: Effect of cardiovascular agents.
Ment Health Clin
July 2016
Chair and Associate Professor, Department of Pharmacy Practice, School of Pharmacy, College of Health Professions, North Dakota State University, Fargo, North Dakota; Adjunct Associate Professor of Neurology, Feinberg School of Pharmacy, Northwestern University, Chicago, Illinois,
Introduction: Cardiovascular agents can be associated with a negative effect on cognition, especially in older adults, critically ill people, and those with baseline cognitive impairment. Negative effect on cognition is commonly reported as uncomplicated acute confusion and delirium and, less commonly, chronic cognitive changes due to drug-induced depression and/or dementia.
Methods: A literature review of case reports, case series, prospective cohort studies, clinical trials, and literature reviews were included in this study.
Schizoid neurochemical pathology-induced membrane Na(+)-K+ ATPase inhibition in relation to neurological disorders.
Int J Neurosci
December 2003
Department of Neurology, Medical College Hospital, Trivandrum, Kerala, India.
Psychiatric abnormalities have been described in primary neurological disorders like multiple sclerosis, primary generalized epilepsy, Parkinson's disease, subacute sclerosing panencephalitis (SSPE), central nervous system glioma, and syndrome X with vascular dementia. It was therefore considered pertinent to compare monoamine neurotransmitter pattern in schizophrenia with those in the disorders described above. The end result of neurotransmission is changes in membrane Na(+)-K+ ATPase activity.
View Article and Find Full Text PDFHypothalamic digoxin, hemispheric dominance, and neuroimmune integration.
Int J Neurosci
April 2002
Department of Neurology, Medical College Hospital, Trivandrum, Kerala, India.
The isoprenoid pathway produces three key metabolites--digoxin (membrane Na(+)-K+ ATPase inhibitor, regulator of neurotransmitter transport, and immunomodulatory agent), dolichol (regulatory of N-glycosylation of proteins), and ubiquinone (free-radical scavenger). The pathway was assessed in systemic lupus erythematosis with neuropsychiatric manifestations, slow viral diseases (subacute sclerosing panencephalitis [SSPE], and Creutzfeldt-Jakob disease [CJD]) and patients with recurrent respiratory infections. This was also studied for comparison in patients with right hemispheric and left hemispheric dominance.
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