Experimental verification of the ability to alter the sensitivity to fluorophore layers in turbid media by varying illumination-collection geometry is presented. Fiber-optic probes and two-layer, fluorophore-doped, turbid phantoms are used to elucidate the roles of spot size, illumination-collection fiber separation, and probe-sample spacing. Variations in single- and multiple-fiber probe design parameters produce significant changes in the relative sensitivity to sample layers in a manner that agrees with prior computational studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1364/ol.28.000120 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Portable dual-function ratio-type triple-emission molecularly imprinted fluorescence sensor for the simultaneous visual detection of hepatitis A and B viruses.
Anal Chim Acta
January 2025
The key Laboratory for Green Organic Synthesis and Application of Hunan Province, College of Chemistry, Xiangtan University, Xiangtan, 411105, China. Electronic address:
Background: Viral epidemics have long endangered human health and had dramatic impacts on environment and society. The currently known viruses and the rapid emergence of previously unknown viruses lead to an urgent need for effective virus detection strategies. It is important to develop methods that can detect multiple related viruses simultaneously in order to improve detection efficiency and to avoid treatment delays due to misdiagnoses.
View Article and Find Full Text PDFHistoNeXt: dual-mechanism feature pyramid network for cell nuclear segmentation and classification.
BMC Med Imaging
January 2025
Department of Information, Third Affiliated Hospital of Naval Medical University, No. 225 Changhai Road, Yangpu District, 200438, Shanghai, China.
Purpose: To develop an end-to-end convolutional neural network model for analyzing hematoxylin and eosin(H&E)-stained histological images, enhancing the performance and efficiency of nuclear segmentation and classification within the digital pathology workflow.
Methods: We propose a dual-mechanism feature pyramid fusion technique that integrates nuclear segmentation and classification tasks to construct the HistoNeXt network model. HistoNeXt utilizes an encoder-decoder architecture, where the encoder, based on the advanced ConvNeXt convolutional framework, efficiently and accurately extracts multi-level abstract features from tissue images.
A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging.
Nat Commun
January 2025
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
The shortwave infrared (SWIR) region is an ideal spectral window for next-generation bioimaging to harness improved penetration and reduced phototoxicity. SWIR spectral activity may also be accessed via supramolecular dye aggregation. Unfortunately, development of dye aggregation remains challenging.
View Article and Find Full Text PDFCoating of Threads with Fluorescent Curli Fibers for pH Sensing.
ACS Appl Bio Mater
January 2025
Department of Chemical Engineering, McGill University, Montreal, Quebec H3A 0C5, Canada.
Threads coated with bioresponsive materials hold promise for innovative wearable diagnostics. However, most thread coatings reported so far cannot be easily customized for different analytes and frequently incorporate non-biodegradable components. Most optically active thread coatings rely on dyes, which often exhibit irreversible responses.
View Article and Find Full Text PDFFunctional Regrowth of Norepinephrine Axons in the Adult Mouse Brain Following Injury.
eNeuro
January 2025
Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
It is widely believed that axons in the central nervous system of adult mammals do not regrow following injury. This failure is thought, at least in part, to underlie the limited recovery of function following injury to the brain or spinal cord. Some studies of fixed tissue have suggested that, counter to dogma, norepinephrine (NE) axons regrow following brain injury.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!