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Chromosomal gain and mutations of gene in canine high-grade oligodendroglioma.
Vet Pathol
January 2025
The University of Tokyo, Tokyo, Japan.
Canine high-grade oligodendrogliomas (HGOGs) exhibit a high expression of platelet-derived growth factor receptor-α (PDGFRA). We examined mutations and gain of and their association with the PDGFRA expression and proliferation of tumor cells in canine HGOG cases and cell lines. Polymerase chain reaction and sequence analysis revealed expected pathogenic mutations in exons 7 and 8 in 16/34 (47%) cases.
View Article and Find Full Text PDFThe clinical impact of EGFR alterations in elderly glioblastoma patients: results from a real-life cohort.
J Neurooncol
February 2025
Department of Oncology, Comprehensive Cancer Centre Henri Becquerel, Rouen, France.
Background: The incidence of glioblastoma in the elderly population is increasing as the worldwide population ages. The differential and poorer survival in the elderly population compared to younger patients is partially explained. The present study aimed to investigate the clinical impact of epidermal growth factor receptor EGFR-altered glioblastoma in a real-life elderly glioblastoma population.
View Article and Find Full Text PDFCDK4 gene copy number increase and concurrent genetic changes in acral melanoma of a Chinese cohort.
Pathology
February 2025
Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing, China. Electronic address:
Acral melanoma (AM) is the most common subtype of melanoma in the Asian population. Abnormalities in the p16-cyclin D1-CDK4 signalling pathway play a crucial role in the development and progression of AM. However, the CDK4 copy number variations (CNVs) in AM are under-reported.
View Article and Find Full Text PDFHigh prevalence of chromosome 17 in breast cancer micronuclei: a means to get rid of tumor suppressors?
Hum Cell
October 2024
Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Micronuclei (MN), defined as small extra-nuclear chromatin bodies enclosed by a nuclear envelope, serve as noticeable markers of chromosomal instability (CIN). The MN have been used for breast cancer (BC) screening, diagnosis, and prognosis. However, more recently they have gained attention as seats for active chromosomal rearrangements.
View Article and Find Full Text PDFMorphologic and molecular diagnostic criteria of malignancies in biliary strictures.
Histol Histopathol
September 2024
Pathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Article Synopsis
- The diagnosis of benign and malignant biliary strictures is complicated due to limited tissue samples for accurate testing.
- This review highlights the challenges in using cytological and histopathological evaluations and discusses new methods like fluorescence in situ hybridization and Next-Generation Sequencing.
- Recent advancements, including circulating tumor DNA, miRNAs, and DNA methylation, are explored as potential tools for better differentiating biliary strictures.
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