AI Article Synopsis
- Rabbits that are hyperimmunized with Micrococcus lysodeikticus not only produce anti-cell wall antibodies but also significant amounts of anti-immunoglobulins, known as rheumatoid factors, which can disrupt immune responses.
- These rheumatoid factors can show non-precipitating systems during immunodiffusion tests that are typically not evaluated.
- In our experiments, specific rabbit allotypes (d12 and A8) triggered visible immunodiffusion reactions when rheumatoid factors were present, and we found that inhibiting this reaction can aid in identifying these markers in sera without rheumatoid factors.
Article Abstract
Rabbits hyperimmunized with Micrococcus lysodeikticus produce, in addition to anti-cell wall antibodies, considerable amounts of anti-immunoglobulins or rheumatoid factors which can interfere with immune reactions. In particular, in immunodiffusion, they can reveal non precipitating systems for which the immunodiffusion typing sera are usually not tested. In our hands, rabbit allotypes d12 and A8 give rise to visible immunodiffusion reactions in presence of rheumatoid factors. Inhibition of this reaction can be used to type for these markers in sera which do not contain the rheumatoid factors.
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