AI Article Synopsis
- Bacteria have efficient methods for obtaining iron, an essential nutrient, utilizing small molecules called siderophores to transport it.
- Enterobactin, a well-studied siderophore, has a unique chemical structure and showcases the complexities of iron uptake in bacteria.
- Recent discoveries include corynebactin, a similar molecule found in Gram-positive bacteria, and insights into how ferric enterobactin interacts with human immune proteins.
Article Abstract
Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is a triscatechol derivative of a cyclic triserine lactone. Studies of the chemistry, regulation, synthesis, recognition, and transport of enterobactin make it perhaps the best understood of the siderophore-mediated iron uptake systems, displaying a lot of function packed into this small molecule. However, recent surprises include the isolation of corynebactin, a closely related trithreonine triscatechol derivative lactone first found in Gram-positive bacteria, and the crystal structure of a ferric enterobactin complex of a protein identified as an antibacterial component of the human innate immune system.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152965 | PMC |
| http://dx.doi.org/10.1073/pnas.0630018100 | DOI Listing |
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