Rhodococcus equi and species of Nocardia and Gordonia may be human opportunistic pathogens. We find that these, as well as several isolates from closely related genera, are highly susceptible to the imidazoles bifonazole, clotrimazole, econazole, and miconazole, whose MICs are =1 micro g/ml. In liquid cultures 1 micro g of the drug/ml was bacteriostatic and 10 micro g/ml was bactericidal. On solid media at 10 micro g of azole/ml no resistant mutants could be isolated. An MIC of 1 to 15 micro g/ml was observed with ketoconazole, whereas none of these organisms was inhibited by the triazoles fluconazole and voriconazole (100 micro g/ml). Imidazoles may offer the prospect of treatment of nocardioform mycetomas and may provide the basis for the development of additional antimicrobial agents to combat these pathogens.
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http://dx.doi.org/10.1128/AAC.47.4.1476-1478.2003 | DOI Listing |
Expert Rev Vaccines
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Department of Expanded Program on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Introduction: Pertussis poses a significant threat to infants under six months due to their immature immune systems, limited maternal antibody protection, and constraints in the vaccination schedule. Despite vaccination efforts, this group remains highly susceptible to severe complications. Addressing these challenges is crucial for improving the health outcomes of infants in China.
View Article and Find Full Text PDFJ Epidemiol Glob Health
January 2025
Neurology Department, King Abdulaziz University, Jeddah, Saudi Arabia.
Sleep is influenced by various factors, including social, economic, genetic, and medical factors, and work and study schedules. Medical students are highly susceptible to sleep-related problems. In this study, we aimed to evaluate the sleep patterns and quality of medical students and determine their correlation with academic achievement.
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February 2025
Division of Bioinformatics and Statistics, The FDA's National Center for Toxicological Research, Jefferson, Arkansas, USA.
Background And Aims: Acute liver failure (ALF) is a serious condition, typically in individuals without prior liver disease. Drug-induced ALF (DIALF) constitutes a major portion of ALF cases. Our research aimed to identify potential genetic predispositions to DIALF.
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Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China.
DO and HO, as two important solvents with very similar properties, play a pivotal role in nuclear industrial production, life and scientific research. Unfortunately, DO and HO are highly susceptible to contamination by each other, so effective qualitative and quantitative analyses of both are necessary. This review comprehensively discusses the progress in optical sensing for the detection of a trace amount of HO in heavy water or , mainly including five types of analytical systems: inorganic nanocrystals, carbon-based nanomaterials, lanthanide complexes, organic polymers, and organic small molecules.
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