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Asymptomatic hyperuricemia should be treated only if the plasma uric acid levels are around 10 mg/100 ml or more on several determinations. In addition, patients on a purine-free diet who excrete more than 600 mg uric acid per 24 h should be treated. In both cases, treatment is intended to be prophylactic against gouty nephropathy. At present there is no evidence that primary hyperuricemia alone is a risk factor for early atherosclerosis and especially coronary artery disease. However, more attention should be paid to the accompanying risk factors such as obesity, hyperlipoproteinemia, diabetes mellitus and hypertension.
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Ann Ital Chir
March 2025
Department of Orthopedics, Dongtai People's Hospital, 224200 Yancheng, Jiangsu, China.
Aim: To evaluate the postoperative analgesic efficacy and safety of ketorolac tromethamine in tibial plateau fracture (TPF) patients undergoing open reduction and internal fixation (ORIF) surgery.
Methods: This retrospective cohort study included 194 TPF patients treated at Dongtai People's Hospital between October 2022 and March 2024. Patients meeting the inclusion criteria were divided into two groups: the ketorolac tromethamine group (n = 104), who received ketorolac tromethamine combined with imrecoxib, and the control group (n = 90), who received imrecoxib alone after ORIF.
Joint Bone Spine
March 2025
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan; Chiba Health Promotion Center, East Japan Railway Company, Chiba, Japan.
Elevated serum uric acid levels are the essential pathophysiology of gout. Although gout rarely develops in childhood, chronic persistent hyperuricemia can induce precipitation and deposition of sodium urate crystals, leading to the development of gout. Hyperuricemia is caused by increased uric acid production and/or decreased uric acid excretion capacity of the kidneys and/or intestinal tract.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
March 2025
Department of Women Health Care, Wuxi School of Medicine, Wuxi Maternal and Child Health Hospital, Jiangnan University, Wuxi, 214002, Jiangsu Province, PR China.
Background: HELLP (Hemolysis, elevated liver enzymes, and low platelets) syndrome is a dangerous obstetric condition that is in great need of simple and inexpensive non-invasive early predictors, but it has been poorly studied. This study was conducted to investigate the predictive role of serum gamma-glutamyl transpeptidase to platelet ratio (GPR) during pregnancy in HELLP syndrome and its adverse pregnancy outcomes.
Methods: This was a retrospective study in a tertiary hospital.
Sci Rep
March 2025
Center for Reproductive Medicine, Traditional Chinese Medicine Hospital of Meishan, Meishan, 620010, China.
Studies have shown that postmenopausal women have more metabolic abnormalities than premenopausal women. No consensus exists on how serum uric acid (sUA) affects metabolism-associated fatty liver disease (MAFLD) in postmenopausal women.This prospective observational study examined this link using National Health and Nutrition Examination Survey (NHANES) 2017 to 2020 data.
View Article and Find Full Text PDFSci Rep
March 2025
Division of Gastroenterology and Nephrology, Tottori University Faculty of Medicine, Nishi-cho 36-1, Yonago, Tottori, 683-8504, Japan.
Although hyperuricemia is associated with chronic kidney disease (CKD), the impact of uric acid (UA)-lowering drugs on CKD has been controversial. Previous investigations have primarily included xanthine oxidase inhibitors; therefore, research of dotinurad, a recently developed selective urate reabsorption inhibitor, is necessary. This retrospective study included 58 patients with CKD; of these, 29 newly initiated dotinurad and 29 initiated febuxostat.
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