Background: Children with Down syndrome have sensory integrative dysfunction as a result of limited sensory experience from lack of normal motor control. The aim of the present study was to compare the effects of sensory integrative therapy alone, vestibular stimulation in addition to sensory integrative therapy and neurodevelopmental therapy, on children with Down syndrome.
Methods: The present study was carried out at the Occupational Therapy Unit, School of Physical Therapy and Rehabilitation of Hacettepe University. Forty-five children who were diagnosed as having Down syndrome by the Departments of Paediatric Neurology and Medical Genetics at Hacettepe University were assessed and randomly divided into three groups. Sensory integrative therapy was given to the first group (n=15), vestibular stimulation in addition sensory integrative therapy was given to the second group (n=15) and neurodevelopmental therapy was given to the third group (n=15). All children were evaluated with Ayres Southern California Sensory Integration Test, Pivot Prone Test, Gravitational Insecurity Test and Pegboard Test. The hypotonicity of extensor muscles, joint stability, automatic movement reactions and locomotor skills were tested. Treatment programs were 1.5 h per session, 3 days per week for 3 months.
Results: When these groups were compared, statistically significant differences were found in subjects' performance of balance on right foot-eyes open, pivot prone position-quality score and locomotor skills-front tests (P<0.05). There were no significant differences in the other tests (P>0.05).
Conclusions: The results of the present study showed that sensory integration, vestibular stimulation and neurodevelopmental therapy were effective in children with Down syndrome. It was concluded that when designing rehabilitation programs for children with Down syndrome, all treatment methods should be applied in combination, and should support each other according to the individual needs of the child.
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http://dx.doi.org/10.1046/j.1442-200x.2003.01670.x | DOI Listing |
Neuroimage
January 2025
Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Brain and Education Innovation, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China; Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China; NYU-ECNU Institute of Brain and Cognitive Science, New York University Shanghai, Shanghai, China. Electronic address:
Environmental and social changes during early school age have a profound impact on brain development. However, it remains unclear how the brains of typically-developing children adjust white matter to optimize network topology during this period. This study aims to propose the fiber length distribution as a novel nodal metric to capture the continuous maturation of brain network.
View Article and Find Full Text PDFNeurology
February 2025
Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, People's Republic of China.
Background And Objectives: Mitochondrial disorders are multiorgan disorders resulting in significant morbidity and mortality. We aimed to characterize death-associated factors in an international cohort of deceased individuals with mitochondrial disorders.
Methods: This cross-sectional multicenter observational study used data provided by 26 mitochondrial disease centers from 8 countries from January 2022 to March 2023.
Front Psychol
January 2025
College for Health, Community, and Policy, The University of Texas at San Antonio, San Antonio, TX, United States.
Objective: This study aimed to evaluate the effectiveness of combining basketball training with a traditional sensory integration therapy (SIT) vs. a SIT alone in enhancing sensory integration capability among Chinese children diagnosed with mild challenges in sensory integration and sensory processing (CSISP).
Methods: This study comprised a Control group and an Experimental group, both undergoing a 10-week intervention (4 sessions/week, 45 min/session).
eNeuro
January 2025
Department of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06030
The study of the neural circuitry underlying complex mammalian decision-making, particularly cognitive flexibility, is critical for understanding psychiatric disorders. To test cognitive flexibility, as well as potentially other decision-making paradigms involving multimodal sensory perception, we developed FlexRig, an open-source, modular behavioral platform for use in head-fixed mice. FlexRig enables the administration of tasks relying upon olfactory, somatosensory, and/or auditory cues and employing left and right licking as a behavior readout and reward delivery mechanism.
View Article and Find Full Text PDFNeuroscience
January 2025
Departamento de Ciencias Médicas y de la Vida, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán, Mexico; Laboratorio de Conducta Animal, Departamento de Psicología, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán, Mexico.
Motor actions adapt dynamically to external changes through the brain's ability to predict sensory outcomes and adjust for discrepancies between anticipated and actual sensory inputs. In this study, we investigated how changes in target speed (v) and direction influenced visuomotor responses, focusing on gaze and manual joystick control during an interception task. Participants tracked a moving target with sinusoidal variations in v and directional changes, generating sensory prediction errors and requiring real-time adjustments.
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