TGICL is a pipeline for analysis of large Expressed Sequence Tags (EST) and mRNA databases in which the sequences are first clustered based on pairwise sequence similarity, and then assembled by individual clusters (optionally with quality values) to produce longer, more complete consensus sequences. The system can run on multi-CPU architectures including SMP and PVM.
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A Mini-Review on Gene Therapy in Glaucoma and Future Directions.
Int J Mol Sci
October 2024
Department of Ophtalmology, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iaşi, Romania.
Glaucoma is a group of optic neuropathies characterized by the degeneration of retinal ganglion cells and the loss of their axons in the optic nerve. The only approved therapies for the treatment of glaucoma are topical medications and surgical procedures aimed at lowering intraocular pressure. Gene therapy involves the insertion, removal, or modification of genetic material within cells to repair or compensate for the loss of a gene's function.
View Article and Find Full Text PDFThe Delayed Turnover of Proteasome Processing of Myocilin upon Dexamethasone Stimulation Introduces the Profiling of Trabecular Meshwork Cells' Ubiquitylome.
Int J Mol Sci
September 2024
IRCCS-Fondazione Bietti, 00168 Rome, Italy.
Glaucoma is chronic optic neuropathy whose pathogenesis has been associated with the altered metabolism of Trabecular Meshwork Cells, which is a cell type involved in the synthesis and remodeling of the trabecular meshwork, the main drainage pathway of the aqueous humor. Starting from previous findings supporting altered ubiquitin signaling, in this study, we investigated the ubiquitin-mediated turnover of myocilin (MYOC/TIGR gene), which is a glycoprotein with a recognized role in glaucoma pathogenesis, in a human Trabecular Meshwork strain cultivated in vitro in the presence of dexamethasone. This is a validated experimental model of steroid-induced glaucoma, and myocilin upregulation by glucocorticoids is a phenotypic marker of Trabecular Meshwork strains.
View Article and Find Full Text PDFPrevalence of Glu323Lys Mutation of the Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso.
J Curr Glaucoma Pract
January 2023
Department of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou 01, Burkina Faso; Department of Laboratory of Molecular and Genetic Biology (LABIOGENE), Joseph KI-ZERBO University, Ouagadougou 03, Burkina Faso; Faculty of Medicine, Saint Thomas Aquinas University (USTA), Ouagadougou 06, Burkina Faso.
Aim: Glaucoma is a group of degenerative diseases of the optic nerve whose predisposing factors may be genetic. The objective of this study was to estimate the frequency of the Glu323Lys mutation as a genetic risk factor for glaucoma.
Materials And Methods: A cross-sectional study over 6 months from October 2020 to March 2021 in Ouagadougou, Burkina Faso.
Increased Production of Riboflavin by Coordinated Expression of Multiple Genes in Operons in .
ACS Synth Biol
May 2022
Key Laboratory of Industrial Biotechnology of the Ministry of Education, Laboratory of Applied Microorganisms and Metabolic Engineering, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
Riboflavin is an essential vitamin widely used in the food, pharmaceutical, and feed industries. However, the insufficient supply of precursors caused by the imbalance of intracellular metabolic flow limits the riboflavin synthesis by industrial strains. Here, we increase riboflavin production by tuning multiple gene expression to balance intracellular metabolic flow.
View Article and Find Full Text PDFCyanorak v2.1: a scalable information system dedicated to the visualization and expert curation of marine and brackish picocyanobacteria genomes.
Nucleic Acids Res
January 2021
Sorbonne Université & CNRS, UMR 7144 'Adaptation & Diversity in the Marine Environment' (AD2M), Station Biologique de Roscoff (SBR), 29680 Roscoff, France.
Cyanorak v2.1 (http://www.sb-roscoff.
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