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CT-based nomogram predicts esophageal gastric variceal bleeding in noncirrhotic portal hypertension caused by hepatic schistosomiasis.
BMC Med Inform Decis Mak
January 2025
Department of Vascular and Wound Center, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Background: To construct a nomogram combining CT varices vein evaluation and clinical laboratory tests for predicting the risk of esophageal gastric variceal bleeding (EGVB) in patients with noncirrhotic portal hypertension (NCPH).
Methods: A total of 315 NCPH patients with non-EGVB and EGVB were retrospectively enrolled and randomly divided into training and testing cohorts. Thirteen collateral vessels were identified and evaluated after CT portal vein system reconstruction.
Hepatosplenic schistosomiasis, treatment outcomes and associated factors among adult patients treated at public hospitals in the Harari Region of Ethiopia: retrospective cross-sectional study.
Trans R Soc Trop Med Hyg
November 2024
School of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, P.O. Box 235, Ethiopia.
Background: Schistosomiasis is one of the neglected tropical diseases that pose a significant burden in developing countries, particularly in sub-Saharan Africa. Hepatosplenic schistosomiasis (HSS) is a substantial cause of morbidity and mortality. This study aimed to determine clinical patterns, outcomes and factors associated with HSS in the Harari Region of Ethiopia.
View Article and Find Full Text PDFinfection and hepatocellular carcinoma: a comorbidity study.
J Parasit Dis
December 2024
Department of Parasitology, Medical Research Institute, University of Alexandria, 165 El Horreya avenue, El Hadara, Alexandria, Egypt.
Background: The implication of human () infection in concomitance with other risk factors such as hepatitis C virus (HCV) and hepatitis B virus (HBV) in the development of hepatocellular carcinoma (HCC) is still under controversy. This work aimed. to evaluate the role of infection in association with hepatitis B virus (HBV), hepatitis C virus (HCV) and other risk factors in the development and/or progress of HCC.
View Article and Find Full Text PDFArticle Synopsis
- Issue 47-6 of the Biomedical Journal discusses the link between anemia and the gut microbiome, and how COVID-19 affects blood oxygenation and red blood cell biology due to SARS-CoV-2 variant spike proteins.
- * The journal also highlights a Taiwanese fungus that may help treat pulmonary fibrosis and explores how co-infections in schistosomiasis could be aided by changes in macrophage receptor signaling.
- * Additionally, it features a genomic study on a significant gene locus related to Tourette syndrome in Taiwanese patients and reviews the detection of common bile duct dilatation in pediatric cases.
Multi-omics analyses of Bacillus amyloliquefaciens treated mice infected with Schistosoma japonicum reveal dynamics change of intestinal microbiome and its associations with host metabolism.
PLoS Negl Trop Dis
October 2024
Human Microbiome and Health Group, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Article Synopsis
- Schistosomiasis japonica causes serious health issues, damaging the intestine and liver, and probiotic therapy, particularly involving Bacillus amyloliquefaciens, may help alleviate these problems.
- The study examined how B. amyloliquefaciens affects the intestinal microbiome in infected mice, finding it promotes beneficial bacteria and stabilizes microbial communities while altering metabolic gene expression related to lipids and amino acids.
- Findings suggest that B. amyloliquefaciens can restore gut microbiota balance and influence host metabolism, highlighting its potential as a treatment option for schistosomiasis japonica.
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