AI Article Synopsis
- The study recorded the activity of myelinated afferents from the dorsal roots of Spontaneously Hypertensive rats (SHR) and those with mechanical hypersensitivity after sciatic nerve injury.
- Control SHR had a higher paw withdrawal threshold to mechanical stimulation compared to Sprague-Dawley (SD) rats, indicating less sensitivity to pain.
- The differences in pain response between SHR and SD rats are likely linked to central nervous system mechanisms instead of variations in the properties of myelinated afferents.
Article Abstract
The activity of single myelinated afferents was recorded from dorsal roots L4-5 in normal Spontaneously Hypertensive rats (SHR) and animals that developed mechanical hypersensitivity following ischemic injury to the sciatic nerve. Control and neuropathic SHRs had significantly higher paw withdrawal threshold to mechanical stimulation than control and neuropathic Sprague-Dawleys (SD). In the SHR rats the mechanical response properties of afferents conducting through the injury site were similar to normals and many of the afferents not conducting through the injury site had spontaneous activity. The only significant difference between the two strains was a faster conduction velocity in afferents recorded from SHR than SD rats. Thus, the behavioral hyposensitivity and less development of mechanical allodynia of SHR rats, compared to SD is not due to differences in the properties of myelinated afferents, but probably involves differences in central inhibitory mechanisms in the two strains.
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| http://dx.doi.org/10.1016/s0304-3940(03)00076-4 | DOI Listing |
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