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Monitoring Public Health Through a Comprehensive Primary Care Database in the Netherlands: Overview of the Nivel Syndromic Surveillance System.
JMIR Public Health Surveill
March 2025
Nivel - Netherlands Institute for Health Services Research, Otterstraat 118, Utrecht, 3513 CR, The Netherlands, 31 629034652.
Background: Syndromic surveillance systems are crucial for the monitoring of population health and the early detection of emerging health problems. Internationally, there are numerous established systems reporting on different types of data. In the Netherlands, the Nivel syndromic surveillance system provides real-time monitoring on all diseases and symptoms presented in general practice.
View Article and Find Full Text PDFThe transcription factor GmbZIP131 enhances soybean salt tolerance by regulating flavonoid biosynthesis.
Plant Physiol
March 2025
College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China.
Detoxifying reactive oxygen species (ROS) that accumulate under saline conditions is crucial for plant salt tolerance. The Salt Overly Sensitive (SOS) pathway functions upstream, while flavonoids act downstream, in ROS scavenging under salt stress. However, the potential crosstalk between the SOS pathway and flavonoids in regulating salt stress responses and the associated mechanisms remain largely unexplored.
View Article and Find Full Text PDFAging and neurodegeneration: when systemic dysregulations affect brain macrophage heterogeneity.
J Immunol
March 2025
INSERM U1015, Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, Villejuif, 94805, France.
Microglia, the major population of brain resident macrophages, differentiate from yolk sac progenitors in the embryo and play multiple nonimmune roles in brain organization throughout development and life. Various microglia subtypes have been described by transcriptomic and proteomic signatures, involved metabolic pathways, morphology, intracellular complexity, time of residency, and ontogeny, both in development and in disease settings. Such macrophage heterogeneity increases with aging or neurodegeneration.
View Article and Find Full Text PDFVirulent African swine fever virus infection of porcine monocytes causes SLA I subversion due to loss of proper ER structure/function.
J Immunol
February 2025
Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Immunology, Greifswald-Isle of Riems, Germany.
African swine fever virus (ASFV) is a large DNA virus of the Asfarviridae family that causes a fatal hemorrhagic disease in domestic swine and wild boar. Infections with moderately virulent strains predominantly result in a milder clinical course and lower lethality. As target cells of ASFV, monocytes play a crucial role in triggering T-cell-mediated immune defense and ASF pathogenesis.
View Article and Find Full Text PDFPrecise Identification of Inhibitors for Coagulation Reactions from Complex Extracts through Monitoring of Biological Aggregates Combined with a Targeted Fishing Technique.
Anal Chem
March 2025
Department of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China.
Biological aggregates play a crucial role in the pathogenesis of thrombotic diseases, especially thrombin-induced biological aggregates. Therefore, the efficient discovery of thrombin inhibitors is of great significance for the prevention and treatment of thrombotic diseases. In this study, the aggregation precursor protein fluorescent probe was successfully prepared for monitoring the production of biological aggregates induced by thrombin.
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