Medical records of patient treated in I Department of Psychiatry Medical University of Gdansk in 1996-2000 were analysed. Carbamazepine was used in 383 patients, 209 male and 174 female. Mean age for the whole group 41.2 years, for male 40.6, for female 41.9. Carbamazepine was mainly used in affective disorders (F30-33) and organic affective disorders (F06.3)-107 persons. Second the most common indication was organic personality disturbances (F07.0)-121 persons. Carbamazepine was used in 100-1200 mg per day (mean dose 415 mg) during 5-189 days (mean 36 days). Treatment was well tolerated. Only 24 patients (6.3%) have mild side effects. Drug level in blood was checked in 19 patients during two last years of analysed material. Carbamazepine was used mainly with tricyclic antidepressants (30.3%), second generation antidepressive drugs (22.2%) and typical neuroleptics (11.1%). More than half of patients (55.6%) were recovered. Based on clinical material carbamazepine seems to be active agent in treatment of affective disorders and diseases connected with organic brain lesion.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Social cognition in bipolar I and II disorders: an updated systematic review and meta-analysis.
BMC Psychiatry
January 2025
School of Nursing, Hangzhou Normal University, Hangzhou, 311121, China.
Objective: In recent years, there has been a rapid increase in reports upon social-cognition impairments in bipolar disorder. This study aimed to compare the characteristics of social cognition domains in bipolar I (BD I) and II (BD II) based on the findings to date.
Methods: A systematic literature search was conducted on Web of Science and PubMed from inception to 28 August 2024.
Neurophysiological correlates of ketamine-induced dissociative state in bipolar disorder: insights from real-world clinical settings.
Mol Psychiatry
January 2025
Siena Brain Investigation and Neuromodulation Lab, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Ketamine, a dissociative compound, shows promise in treating mood disorders, including treatment-resistant depression (TRD) and bipolar disorder (BD). Despite its therapeutic potential, the neurophysiological mechanisms underlying ketamine's effects are not fully understood. This study explored acute neurophysiological changes induced by subanesthetic doses of ketamine in BD patients with depression using electroencephalography (EEG) biomarkers.
View Article and Find Full Text PDFNetwork pharmacology combined with experimental verification for exploring the potential mechanism of phellodendrine against depression.
Sci Rep
January 2025
College of Basic Medicine, Shanxi University of Chinese Medicine, No. 121 DaXue Street, Jinzhong, 030619, China.
The anti-inflammatory effect of phellodendrine (PHE), derived from Phellodendri Chinensis Cortex, has been verified in previous studies. Major depressive disorder (MDD) is associated with immune dysregulation and inflammatory processes. This study aimed to explore the therapeutic effects of PHE on MDD through network pharmacology and experimental validation.
View Article and Find Full Text PDFEfficacy and Safety of Home-Based Transcranial Direct Current Stimulation as Adjunct Treatment for Cognitive Improvement in Major Depressive Disorder: A Double-Blind, Randomized, Multi-Site Clinical Trial.
Eur Psychiatry
January 2025
Department of Psychiatry, Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Research status, hotspots, and implications of seasonal affective disorder: A bibliometric analysis based on CiteSpace and VOSviewer.
Medicine (Baltimore)
November 2024
The Second Affiliated Hospital of Zhejiang Chinese Medical University (Xinhua Hospital of Zhejiang Province), Hangzhou, Zhejiang, China.
The objective was to determine the research status and hotspots of seasonal affective disorders (SAD) based on bibliometric tools, which will contribute to the further research in this field. We used bibliometric tools CiteSpace and VOSviewer to conduct visual quantitative analysis on 465 SAD literatures in the Web of Science core database from 2008 to 2023 from multiple perspectives such as collaboration network, keywords, and literature citations. At the same time, we used Microsoft Word to make relevant tables.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!