16 patients (9 female, 7 male; mean age 32.69 +/- 10.30) with coexisting obsessive-compulsive disorder (OCD) and depression were treated for 6 weeks with citalopram (10-60 mg; mean dosage after 6 weeks--25.71 +/- 12.83 mg). Their mental state was evaluated in the 7th, 14th, 28th and 42nd of treatment by the use of psychiatric examination and self-assessment clinical scales. After 6 weeks of treatment 5 patients were in full remission, 7 in partial remission (totally 75% of patients were responders) and 4 still suffered from OCD or depressive symptoms. In the 1st week of treatment 5 patients complained on temporary aggravation of symptoms but it turned out to have no prognostic value. It is recommended to find early signs of final clinical response.
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