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[Liquid biopsy in retinoblastomas].
Ophthalmologie
December 2024
Augenklinik der Universitätsmedizin Essen, Essen, Deutschland.
The liquid biopsy is playing an increasingly more important role in the diagnosis and treatment of retinoblastomas. The possibility of safe and uncomplicated retrieval and examination of aqueous humour from the anterior chamber contributes significantly to the differential diagnosis and to a better understanding of the disease. It helps with the prognosis both in terms of eye-preserving treatment and in estimating the risk of metastatic disease and helps with genetic uncertainties in unilateral disease.
View Article and Find Full Text PDFRNA-seq transcriptomic profiling of TGF-β2-exposed human trabecular meshwork explants: Advancing insights beyond conventional cell culture models.
Exp Cell Res
October 2024
Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, IHU Foresight, Paris, France; Sorbonne Université, INSERM, CNRS, IHU Foresight, Institut de La Vision, Paris, France. Electronic address:
Article Synopsis
- - Primary open-angle glaucoma (POAG) is a major cause of vision loss linked to high intraocular pressure (IOP), with the trabecular meshwork (TM) being essential for regulating IOP by filtering aqueous humor.
- - The study investigates the effects of the TGF-β2 signaling pathway on TM dysfunction using human TM explants, revealing changes in gene expression associated with extracellular matrix regulation and fibrotic signaling through bulk RNA sequencing.
- - Findings highlight TGF-β2's impact on molecular pathways, including BMP and Wnt signaling, which may provide insights for developing treatments targeting these mechanisms to prevent TM dysfunction in glaucoma.
Selective Upregulation of Interleukin 1 Receptor Antagonist and Interleukin-8 in Fuchs' Endothelial Corneal Dystrophy with Accompanying Cataract.
J Clin Med
May 2024
Health Promotion and Obesity Management, Pathophysiology Department, Medical University of Silesia in Katowice, 40-752 Katowice, Poland.
(1) : Patients with Fuchs' endothelial corneal dystrophy (FECD) may have coexisting cataracts and, therefore, may require a cataract surgery, which poses challenges due to potential endothelial cell damage. FECD is a degenerative eye disease of unclear etiology, with inflammatory cytokines maybe playing an important role in its development and progression. The present study aimed to investigate the cytokine profile in the aqueous humor of FECD eyes with cataract.
View Article and Find Full Text PDFAnalysis of risk factors associated with secondary open-angle glaucoma in Posner-Schlossman syndrome: A retrospective case-control study.
Front Med (Lausanne)
January 2023
The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Background: Posner-Schlossman syndrome (PSS) is a relatively rare cause of chronic secondary open-angle glaucoma (OAG), but the exact cause is unknown. This study aimed to determine potential risk factors for OAG secondary to PSS and to provide a basis for early intervention in the development of PSS.
Methods: This was a retrospective case-control study.
Angiogenic footprints in diabetic retinopathy: opportunities for drug development.
Biotechnol Genet Eng Rev
April 2023
Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju, Korea.
Diabetic retinopathy is one of the withering disorders that has been making the lives of patients miserable. Arising as a result of chronic high blood sugar levels in diabetes patients, retinopathy has become a major reason causing permanent blindness, retinal detachment, vitreous humor, rage, or glaucoma among patients. Angiogenesis being the major culprit behind the development of this condition is the growth of new blood vessels from the earlier ones existing.
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