AI Article Synopsis
- The study aimed to assess how intramuscular injections of hydromorphone and acepromazine affect intraocular pressure (IOP) and pupil size (PS) in dogs.
- Seventeen healthy dogs were tested, having their IOP and PS measured before and after receiving the medications.
- Results showed a slight decrease in IOP but no significant change, while a majority of the dogs exhibited marked pupil constriction (miosis) after the injections.
Article Abstract
Objective: To investigate the effects of intramuscularly administered hydromorphone hydrochloride and acepromazine on intraocular pressure (IOP) and pupil size (PS).
Animals Studied: Seventeen dogs free of clinically relevant ocular abnormalities.
Procedure: Measurements of IOP and PS were obtained and the dogs were injected intramuscularly with hydromorphone (0.04-0.08 mg/kg) and acepromazine (0.04 mg/kg). Measurements of IOP and PS were repeated 10 min and 25 min later.
Results: Though a decreasing trend in IOP values was demonstrated, no significant difference was noted in IOP from the initial examination to examination following intramuscular administration of hydromorphone and acepromazine. Significant miosis was present in 16 of 17 dogs at 10 min and 25 min following administration of hydromorphone and acepromazine.
Conclusion: Hydromorphone (0.04-0.08 mg/kg) and acepromazine (0.04 mg/kg) cause significant miosis in dogs at 10 and 25 min following intramuscular administration.
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| http://dx.doi.org/10.1046/j.1463-5224.2003.t01-1-00273.x | DOI Listing |
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