A novel series of benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 31 is orally active in a carrageenan-induced rat hyperalgesia model of pain and shows no motor coordination side effects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0960-894x(02)01061-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SAFETY, PHARMACOKINETICS, AND CLINICAL EFFICACY OF ADS051, A NEUTROPHIL MODULATOR, IN ULCERATIVE COLITIS: RESULTS OF A RANDOMIZED PHASE 1B TRIAL.
Am J Gastroenterol
December 2024
Adiso Therapeutics, Inc, Concord, Massachusetts, USA.
Objectives: Ulcerative colitis (UC) is characterized by colonic inflammation, with neutrophils playing a key role in UC activity, prognosis, and response to therapies. Current UC therapeutics can have significant side effects and limited efficacy. ADS051 is a novel, oral, gut-restricted small molecule that modulates neutrophil migration and activation without in vitro suppression of T-cell activation.
View Article and Find Full Text PDFThe plaque reducing efficacy of oil pulling with sesame oil: a randomized-controlled clinical study.
Clin Oral Investig
January 2025
University Hospital for Conservative Dentistry and Periodontology, Medical University of Innsbruck, Innsbruck, 6020, Austria.
Objectives: To compare the plaque reducing efficacy of oil pulling with sesame oil compared to distilled water in a randomized, controlled, examiner-blinded parallel group study.
Materials And Methods: Forty probands without advanced periodontal disease of the University Hospital for Restorative Dentistry and Periodontology, Medical University of Innsbruck (Austria) were randomized allocated to test- (sesame oil) or control group (distilled water) and asked to pull daily in the morning for eight weeks with their allotted fluid for 15 min. Rustogi Modified Navy Plaque Index (RMNPI) and gingival bleeding index were assessed at baseline and after four and eight weeks.
Developing Topics.
Alzheimers Dement
December 2024
The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Background: Brain rhythms provide the timing for recruitment of brain activity required for linking together neuronal ensembles engaged in specific tasks. The γ-oscillations (30-120 Hz) orchestrate neuronal circuits underlying cognitive processes and working memory. High temporal resolution recording methods, such as magnetoencephalography, have made it clear that Alzheimer's disease (AD) patients, starting as early as the mild cognitive impairment (MCI) stage, have diminished γ-oscillations even before the Aβ load takes full effect.
View Article and Find Full Text PDFBackground: Lecanemab has been approved by the FDA for patients with early Alzheimer's disease (AD). NA-831 is an experimental drug that has showed a proof of safety and efficacy in Phase 2 clinical trial for patients with early Alzheimer's disease. AD patients are treated with a number of comedications not only to address cognitive impairment (standard-of-care) but also other comorbidities.
View Article and Find Full Text PDFBackground: Adult Hippocampal Neurogenesis has been shown to be involved in Major Depressive Disorder (MDD) and Alzheimer's disease (AD) pathology. NA-831 is a small drug molecule, exhibiting neuroprotection, neurogenesis and memory enhancing properties.
Method: For AD: A randomized clinical trial of NA-831 was performed in 112 participants with mild and moderate Alzheimer's disease (AD), half received the drugs and half received placebo.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!