AI Article Synopsis
- - The study investigates how CD33-related siglecs (5, 7, 8, 9, and 10) interact with various gangliosides, revealing distinct binding preferences among them.
- - Siglec-5 shows a strong preference for GQ1b and weakly binds to GT1b, while Siglec-10 interacts exclusively with GT1b.
- - Siglec-7 and siglec-9 bind to gangliosides with a disialoside motif, with siglec-7 being more effective; in contrast, siglec-8 has low affinity for the gangliosides tested, highlighting different selectivity patterns despite their structural similarities.
Article Abstract
Our study deals with the interaction of CD33 related-siglecs-5,-7,-8,-9,-10 with gangliosides GT1b, GQ1b, GD3, GM2, GM3 and GD1a. Siglec-5 bound preferentially to GQ1b, but weakly to GT1b, whereas siglec-10 interacted only with GT1b ganglioside. Siglec-7 and siglec-9 displayed binding to gangliosides GD3, GQ1b and GT1b bearing a disialoside motif, though siglec-7 was more potent; besides, siglec-9 interacted also with GM3. Siglec-8 demonstrated low affinity to the gangliosides tested compared with other siglecs. Despite high structural similarity of CD33 related siglecs, they demonstrated different ganglioside selectivity, in particular to the Neu5Acalpha2-8Neu5Ac motif.
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| http://dx.doi.org/10.1016/s0960-894x(02)00998-8 | DOI Listing |
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