This article analyses the Enquete Permanente Cancer (EPC) (Permanent Cancer Survey), which organized the recording of cancers in France from 1943 onwards. This survey used a new classification of tumours and introduced the notion of stages. For its French authors, defining the different stages of the disease was primarily a question of methodological necessity: standardizing and giving relevance to data which until then has been disparate and scarce. However, by correlating the timing of the initial diagnosis of cancer with the length of asymptomatic periods after anti-cancer treatment, differentiated survival rates could be obtained. For each type of cancer, each stage could be shown to correspond to a greater or lesser probability of lenght of survival. This notion of stages, which was rapidly adopted on the international level as a tool for probabilistic reasoning, was not adopted for the purposes of prognosis in France until the 1960s.
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http://dx.doi.org/10.1093/shm/15.2.291 | DOI Listing |
J Adv Res
January 2025
School of Basic Medical Sciences, Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China. Electronic address:
Background: The genetic variants of LMNA cause an array of diseases that often affect the heart. LMNA-related cardiomyopathy exhibits high-penetrance and early-onset phenotypes that lead to late-stage heart failure or lethal arrhythmia. As a subtype of dilated cardiomyopathy and arrhythmogenic cardiomyopathy, LMNA-related cardiac dysfunction is resistant to existing cardiac therapeutic strategies, leaving a major unmet clinical need in cardiomyopathy management.
View Article and Find Full Text PDFSchizophr Bull
January 2025
Department of Psychiatry, University of Oxford, and Oxford Health NHS Foundation Trust, Warneford Hospital, Warneford Lane, Oxford, OX37JX, United Kingdom.
Background And Hypothesis: Formal thought disorder (FTD), studied even before the inception of the concept of schizophrenia, remains a deeply isolating experience for patients as well as a difficult one for their interlocutors, including clinicians.
Study Design: The views on language, paralinguistic, and extralinguistic features exhibited by patients with severe mental ill health are reviewed, including the contributions from 19th-century European authors to the last third of the 20th century.
Study Results: Stages in the construction of FTD are described, including its merging with Dementia Praecox, and its subsequently being shaped by notions such as primitive archaic thinking, paralogical or autistic thinking, concretism, overinclusive thinking, and the return of the efforts to describing it with increased reliability.
Virchows Arch
January 2025
Institute of Pathology, University Medical Center Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
Penile cancer (PeCa) is a rare disease with poor prognosis in the metastatic stage. Neither effective adjuvant nor palliative therapeutic options are available. Research efforts in this field have so far failed to establish robust predictors of survival.
View Article and Find Full Text PDFEur J Popul
January 2025
Stockholm University Demography Unit, Department of Sociology, Stockholm University, Stockholm, Sweden.
Research has shown that married individuals live longer lives than unmarried women and men. A smaller number of studies have included non-marital cohabitation and have found that their mortality falls between the married and other unmarried groups. There are indications that the cohabiting population is diverse in terms of mortality risk, yet very little is known about how the association is related to age and stages of the life course.
View Article and Find Full Text PDFPhilos Trans R Soc Lond B Biol Sci
January 2025
Department of Natural Resource Sciences and Bieler School of Environment, McGill University, Montreal H9X 3V9, Canada.
Georgina Mace introduced a compelling perspective on the major shifts in conservation science's framing and purpose from 1960 to 2010. A decade ago, she proposed that the conservation community had begun to move into a new framing of 'people and nature' based on changes in perspectives on the relationships between people and nature and new interdisciplinary concepts and methods used in conservation. Progress in using this frame is clear as 'two-way dynamic relationships between people and nature' have since taken centre stage in science, practice and policy.
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