Highly efficient 1,4-addition of 1,3-diesters to conjugated enones by In/TMSCl.

J Org Chem

Department of Chemistry, Kangwon National University, Chunchon 200-701, Republic of Korea.

Published: March 2003

Organoindium reagents derived from indium and diethyl bromomalonates were added to a wide range of conjugated enones in a 1,4-fashion in the presence of TMSCl under mild conditions, and corresponding oxo-1,3-diesters were obtained in good to excellent yields.

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Source
http://dx.doi.org/10.1021/jo026600tDOI Listing

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