We propose new approach to classification of regulatory peptides and proteins. It is based on the complex of their properties: stability, affinity to receptors, existence of specialized percursors, protein-transporters etc. In particular we describe very stable factors such as new peptide family named glyprolines.
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J Transl Med
January 2025
Department of Urology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Background: The progression of bladder cancer (BC) from non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive bladder cancer (MIBC) significantly increases disease severity. Although the tumor microenvironment (TME) plays a pivotal role in this process, the heterogeneity of tumor cells and TME components remains underexplored.
Methods: We characterized the transcriptomes of single cells from 11 BC samples, including 4 NMIBC, 4 MIBC, and 3 adjacent normal tissues.
J Orthop Surg Res
January 2025
Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150001, Heilongjiang Province, China.
Background: Osteoporosis (OP) is a systemic disease characterized by low bone mass. New progress has been made in the study of OP, such as lipid peroxidation. However, the role of lipid peroxides in osteoclast differentiation is still unclear.
View Article and Find Full Text PDFBMC Med Educ
January 2025
Health Professions Education Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Background: Educational research highlights active approaches to learning are more effective in knowledge retention and problem-solving. It has long been acknowledged that adapting to more active ways of learning form part of the challenge for new university students as the pedagogical distance between the didactical approach largely followed by secondary school systems the world over differs quite significantly from the often more student-led, critical approach taken by universities. University students encounter various learning challenges, particularly during the transition from secondary school to university.
View Article and Find Full Text PDFBMC Public Health
January 2025
Unit of Social Pediatrics, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Background: Age-appropriate breastfeeding and adequate complementary feeding play a crucial role in reducing under-5 mortality rates, malnutrition, and mortality worldwide. Given the high prevalence of adolescent pregnancy in Uganda, we aimed to assess the competence of adolescent mothers in infant and young child feeding (IYCF) using data from the 2016 Uganda Demographic Health Survey.
Method: Our sample comprised the last children aged 6-23 months of mothers aged 15-29 years, totaling 2594 mother-infant pairs; 402 were aged 15-19 years, 1,388 were aged 20-29 years with their first delivery before the age of 20, and 804 were aged 20-29 years with their first delivery at 20 years or older.
BMC Public Health
January 2025
Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Background: In an efficient and effective healthcare delivery, good communication plays an essential role. The communicative health literacy (COMM-HL) of the patients is an important attribute, but the number of validated COMM-HL assessment tools is low, and they do not cover all aspects of COMM-HL. That's why a new scale has been developed within an international collaboration.
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