Acute compartment syndrome of the lower extremity is typically associated with some form of trauma, either fracture or blunt injury. Accurate diagnosis and urgent treatment of this condition is required for preservation of the viability of the limb. We report the case of a 73-year-old man who developed an acute compartment syndrome of the leg after diagnostic electromyography. Potential causes and treatment are discussed.
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http://dx.doi.org/10.1002/mus.10328 | DOI Listing |
The stress-induced keratin intermediate filament gene/protein (K16) is spatially restricted to the suprabasal compartment of the epidermis and extensively used as a biomarker for psoriasis, hidradenitis suppurativa, atopic dermatitis and other inflammatory disorders. However, its role in these conditions remains poorly defined. Here we show that K16 negatively regulates type-I interferon (IFN) signaling and innate immune responses.
View Article and Find Full Text PDFCompartment syndrome caused by Streptococcus pyogenes (Group A Streptococcus) has rarely been documented. We report the case of a 53-year-old male, hypertensive, who developed compartment syndrome and myositis in the right lower limb. The patient underwent emergency fasciotomies of the anterior, lateral, superficial posterior and deep posterior compartments of the leg and two subsequent surgical debridements, in addition to receiving antibiotic treatment and delayed closure of the fasciotomies with grafts.
View Article and Find Full Text PDFFront Cell Infect Microbiol
January 2025
Center for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for Prevention of Human Diseases, UTHealth-McGovern Medical School, Houston, TX, United States.
Interstitial lung disease (ILD) is characterized by chronic inflammation and scarring of the lungs, of which idiopathic pulmonary fibrosis (IPF) is the most devastating pathologic form. Idiopathic pulmonary fibrosis pathogenesis leads to loss of lung function and eventual death in 50% of patients, making it the leading cause of ILD-associated mortality worldwide. Persistent and subclinical microbial infections are implicated in the acute exacerbation of chronic lung diseases.
View Article and Find Full Text PDFJ Exp Orthop
January 2025
Department of Clinical Sciences Lund, Orthopaedics, Clinical and Molecular Osteoporosis Research Unit Faculty of Medicine Lund University Lund Sweden.
Purpose: To investigate if hip and knee alignment assessed 2 years after anterior cruciate ligament (ACL) injury is associated with compartment-specific radiographic knee osteoarthritis (OA) 3 years later.
Methods: An exploratory analysis was conducted in the knee ACL, nonsurgical versus surgical treatment (KANON) trial (ISRCTN84752559); 115 subjects with acute ACL injury were assessed at the 2-year follow-up; full-limb images of the injured leg were acquired, and the neck-shaft angle (NSA) and hip-knee-ankle angle (HKA) were measured. At the 5-year follow-up, weight-bearing tibiofemoral and patellofemoral radiographs were obtained.
Ultrasound Med Biol
January 2025
Biomedical Engineering, Cardiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands; Medical Imaging, Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands. Electronic address:
Objective: Assessing myocardial perfusion in acute myocardial infarction is important for guiding clinicians in choosing appropriate treatment strategies. Echocardiography can be used due to its direct feedback and bedside nature, but it currently faces image quality issues and an inability to differentiate coronary macro- from micro-circulation. We previously developed an imaging scheme using high frame-rate contrast-enhanced ultrasound (HFR CEUS) with higher order singular value decomposition (HOSVD) that provides dynamic perfusion and vascular flow visualization.
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