Increasing the output from discovery is currently a major objective for the pharmaceutical industry aimed at reversing recent downward trends in productivity. Although significant attention has been focused on innovative assay and process technologies, these only address specific points in the discovery process. Little effort has been made to manage the multiple interconnected steps within discovery effectively. This manifests itself in low utilization rates of component elements and low expectations of delivery to any agreed timescale.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s1359-6446(03)02612-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Getting Insights in Stakeholder Collaboration in the Transition Toward Safe and Sustainable Food Production: Net-Map Analysis of the Italian Wheat Supply Chain.
Foods
February 2025
Institute of Sciences of Food Production, National Research Council of Italy, Via Amendola 122/O, 70126 Bari, Italy.
The transition toward sustainable food systems is a critical challenge for the European Union (EU), requiring integrated policies and collaborative action. However, the complexity of food systems and the diverse interests of stakeholders often hinder effective progress. To apply a systemic approach and deliver context-specific solutions, it is necessary to establish key commodity/supply chain groups that include diverse perspectives from multiple stakeholders.
View Article and Find Full Text PDFSynthesis, Structure and Iodine Adsorption Properties of a Ni Cluster-Based Supramolecular Framework.
Molecules
February 2025
Strait Institute of Flexible Electronics (SIFE, Future Technologies), Fujian Normal University and Strait Laboratory of Flexible Electronics (SLoFE), Fuzhou 350117, China.
The capture of radioactive iodine (129I or 131I) is of significant importance for the production of nuclear power and the treatment of nuclear waste. In recent years, crystallized porous materials have been extensively investigated to achieve highly effective adsorption of radioactive iodine. Herein, by using the hydrothermal method, a Ni cluster-based framework () was successfully constructed through a self-assembly process.
View Article and Find Full Text PDFRespiratory muscle training reduces painful swallowing and opioid use during radiation therapy for head and neck cancer: a matched pair analysis.
BMC Cancer
March 2025
Dept. Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, USA.
Background: Patients with head and neck cancer (HNC) receiving radiation therapy (RT) are at increased risk for symptoms of oral mucositis (OM), opioid use, and declines in physical function, outcomes that contribute to increased morbidity and mortality. The study objective was to determine the effects of respiratory muscle training (RMT) on OM and opioid use, as well as functional performance in patients with HNC receiving RT with or without concurrent chemotherapy (CCRT).
Methods: Patients aged ≥ 18 years of age with stage I to IV HNC being treated with RT or CCRT receiving a home-based respiratory muscle training (RMT) (n = 20) were compared to a 5:1 matched historical group (n = 100) who did not receive RMT.
Bioinspired gel polymer electrolyte for wide temperature lithium metal battery.
Nat Commun
March 2025
State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Stable operation of Li metal batteries with gel polymer electrolytes in a wide temperature range is highly expected. However, insufficient dynamics of ion transport and unstable electrolyte-electrode interfaces at extreme temperatures greatly hinder their practical applications. We report a bioinspired gel polymer electrolyte that enables high-energy-density Li metal batteries to work stably in a wide temperature range from -30 to 80 °C.
View Article and Find Full Text PDFNegative Enthalpy Doping Stabilizes P2-Type Oxides Cathode for High-Performance Sodium-Ion Batteries.
Adv Mater
March 2025
Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, P. R. China.
P2-type NaNiMnO (NNMO) as cathode material for sodium-ion batteries (SIBs) largely suffers from continuous accumulation of local stress caused by destructive structural evolution and irreversible oxygen loss upon cycling, leading to rapid capacity degradation. Herein, a strategy of negative enthalpy doping (NED), wherein transition metal (TM) sites are substituted with 0.01 mol each Sn, Sb, Cu, Ti, Mg, and Zn to increase the stability of the TM layers, is proposed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!