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Effect of Exogenous of Transforming Growth Factor-β1 on Pregnancy Outcome in Mice with Recurrent Pregnancy Loss by Persistent Enhancement of Placental Tissue Indoleamine 2,3-Dioxygenase Expression.
Int J Fertil Steril
January 2025
Reproductive Medicine Center, Department of Obstetrics and Gynecology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China. Email:
Background: The immunologic factors are the chief reason for recurrent pregnancy loss (RPL) and induction of maternal-fetal tolerance is the main treatment for this cause of RPL, but the effect of this method is uncertainly and needs multiple doses and/or interventions. The aim of this study was to investigate whether a single administration of transforming growth factor-β1 (TGF-β1) can improve the pregnancy outcomes of RPL mice and whether the improvement is cause by TGF-β1 driving the expression of immune tolerance molecule indoleamine 2,3-dioxygenase (IDO).
Materials And Methods: In this experimental study, 40 RPL model mice were equally divided into a control group, that received 0.
Generative Artificial Intelligence: Applications in Scientific Writing and Data Analysis in Wound Healing Research.
Adv Skin Wound Care
January 2025
At the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States, Adrian Chen, BS, Aleksandra Qilleri, BS, and Timothy Foster, BS, are Medical Students. Amit S. Rao, MD, is Project Manager, Department of Surgery, Wound Care Division, Northwell Wound Healing Center and Hyperbarics, Northwell Health, Hempstead. Sandeep Gopalakrishnan, PhD, MAPWCA, is Associate Professor and Director, Wound Healing and Tissue Repair Analytics Laboratory, School of Nursing, College of Health Professions, University of Wisconsin-Milwaukee. Jeffrey Niezgoda, MD, MAPWCA, is Founder and President Emeritus, AZH Wound Care and Hyperbaric Oxygen Therapy Center, Milwaukee, and President and Chief Medical Officer, WebCME, Greendale, Wisconsin. Alisha Oropallo, MD, is Professor of Surgery, Donald and Barbara Zucker School of Medicine and The Feinstein Institutes for Medical Research, Manhasset New York; Director, Comprehensive Wound Healing Center, Northwell Health; and Program Director, Wound and Burn Fellowship program, Northwell Health.
Generative artificial intelligence (AI) models are a new technological development with vast research use cases among medical subspecialties. These powerful large language models offer a wide range of possibilities in wound care, from personalized patient support to optimized treatment plans and improved scientific writing. They can also assist in efficiently navigating the literature and selecting and summarizing articles, enabling researchers to focus on impactful studies relevant to wound care management and enhancing response quality through prompt-learning iterations.
View Article and Find Full Text PDF[The repercussions of variations in ambient air pressure on pulmonary airway dystrophy. Applications to scuba diving with mask, commercial air travel and stays in high-altitude settings].
Rev Mal Respir
December 2024
Service de pneumologie, hôpital de la Croix-Rousse, 69004 Lyon, France.
Article Synopsis
- Pulmonary airway dystrophy (PAD) is a rare condition that can be either inherited or developed, with limited research on how air pressure changes during airplane trips or high-altitude situations impact it.
- Studies indicate that all PAD cases have been linked to accidents during exposure to varying air pressures, necessitating careful consideration of each individual case to tailor recommendations based on the disease's origin and severity.
- Establishing a register for cases of barotrauma in individuals with cystic lung disease or pulmonary bullae related to PAD could provide valuable insights and improve patient management.
Repeated hyperbaric oxygen exposure accelerates fatigue and impairs SR-calcium release in mice.
J Appl Physiol (1985)
December 2024
Center for Hyperbaric Medicine and Environmental Physiology, Department of Anesthesiology, Duke University School of Medicine, Durham, NC, 27710, USA.
Breathing hyperoxic gas is common in diving and accelerates fatigue after prolonged and repeated exposure. The mechanism(s) remain unknown but may be related to increased oxidants that interfere with skeletal muscle calcium trafficking or impair aerobic ATP production. To determine these possibilities, C57BL/6J mice were exposed to hyperbaric oxygen (HBO) for 4-h on three consecutive days or remained in room air.
View Article and Find Full Text PDFElevation of spectral components of electrodermal activity precedes central nervous system oxygen toxicity symptoms in divers.
Commun Med (Lond)
December 2024
Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Background: Oxygen-rich breathing mixtures up to 100% are used in some underwater diving operations for several reasons. Breathing elevated oxygen partial pressures (PO) increases the risk of developing central nervous system oxygen toxicity (CNS-OT) which could impair performance or result in a seizure and subsequent drowning. We aimed to study the dynamics of the electrodermal activity (EDA) and heart rate (HR) while breathing elevated PO in the hyperbaric environment (HBO) as a possible means to predict impending CNS-OT.
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