The striped bass has two retina-expressed class III myosin genes, each composed of a kinase, motor, and tail domain. We report the cloning, sequence analysis, and expression patterns of the long (Myo3A) and short (Myo3B) class III myosins, as well as cellular localization and biochemical characterization of the long isoform, Myo3A. Myo3A (209 kDa) is expressed in the retina, brain, testis, and sacculus, and Myo3B (155 kDa) is expressed in the retina, intestine, and testis. The tails of these two isoforms contain two highly conserved domains, 3THDI and 3THDII. Whereas Myo3B has three IQ motifs, Myo3A has nine IQ motifs, four in its neck and five in its tail domain. Myo3A localizes to actin filament bundles of photoreceptors and is concentrated in the calycal processes. An anti-Myo3A antibody decorates the actin cytoskeleton of rod inner/outer segments, and this labeling is reduced by the presence of ATP. The ATP-sensitive actin association is a feature characteristic of myosin motors. The numerous IQ motifs may play a structural or signaling role in the Myo3A, and its localization to calycal processes indicates that this myosin mediates a local function at this site in vertebrate photoreceptors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151579 | PMC |
| http://dx.doi.org/10.1091/mbc.e02-06-0317 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dentoalveolar characteristics in subjects with different anteroposterior relationships: a retrospective cross-sectional Cone-Beam Computed Tomography study.
BMC Oral Health
December 2024
College of Dental Medicine, QU Health, Qatar University, P.O. Box: 2713, Doha, Qatar.
Background: The collum angle, tooth dimensions, root length, and alveolar bone thickness have a significant impact on orthodontic diagnosis and treatment planning. The boundaries of orthodontic tooth movement are determined by alveolar bone thickness and dimensions while the collum angle determines the appropriate positioning of the root relative to the cortical plate. This study aimed to compare the collum angle, crown dimensions, root length, and alveolar bone thickness of the upper and lower incisors, canines, and premolars in subjects with varying anteroposterior relationships.
View Article and Find Full Text PDFSelf -reported bruxism in patients undergoing Orthodontic treatment - a cross-sectional study.
BMC Oral Health
December 2024
Department of Surgery, Program Director Orthodontics Residency Program, Section of Dentistry, The Aga Khan University Hospital, Stadium Road, P.O Box 3500, Karachi, 74800, Pakistan.
Background: Orthodontic treatment involves manipulation of tooth position that can temporarily lead to occlusal interferences capable of inducing bruxism. The objectives of this study were to determine the self-reported incidence of bruxism and its association with factors such as facial type, divergence, skeletal and dental malocclusions in orthodontic patients.
Materials And Methods: 80 patients who underwent a minimum of six months of orthodontic treatment were surveyed using a validated self-reported bruxism questionnaire for the presence or absence of bruxism.
Pathway to care, treatment and disease burden of pulmonary arterial hypertension: a real-world survey of physicians and patients in Latin America.
BMJ Open
December 2024
Clinical Research Department, Ignacio Chávez National Heart Institute, Mexico City, Mexico
Objectives: To investigate clinical characteristics, symptom profile, testing practices, treatment patterns and quality of life (QoL) among patients with pulmonary arterial hypertension (PAH) in Latin America.
Design: Data from the Adelphi Real World PAH Disease Specific Programme, a cross-sectional survey with retrospective data collection.
Setting: University/teaching hospital, regional centres, private practices and government institutions in Argentina, Brazil, Colombia and Mexico.
MEFA-Net: A mask enhanced feature aggregation network for polyp segmentation.
Comput Biol Med
December 2024
Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing, College of Computer and Data Science, Fuzhou University, Fuzhou 350116, China; Engineering Research Center of Big Data Intelligence, Ministry of Education, Fuzhou 350116, China. Electronic address:
Accurate polyp segmentation is crucial for early diagnosis and treatment of colorectal cancer. This is a challenging task for three main reasons: (i) the problem of model overfitting and weak generalization due to the multi-center distribution of data; (ii) the problem of interclass ambiguity caused by motion blur and overexposure to endoscopic light; and (iii) the problem of intraclass inconsistency caused by the variety of morphologies and sizes of the same type of polyps. To address these challenges, we propose a new high-precision polyp segmentation framework, MEFA-Net, which consists of three modules, including the plug-and-play Mask Enhancement Module (MEG), Separable Path Attention Enhancement Module (SPAE), and Dynamic Global Attention Pool Module (DGAP).
View Article and Find Full Text PDFPredictors of conversion to cesarean section in a French cohort of 236 class III (body mass index of 40 or more) obese women attempting vaginal delivery: A restrospective multicentric study.
Eur J Obstet Gynecol Reprod Biol
November 2024
Public Health and Performance Departement, Champagne Sud Hospital, Troyes, France. Electronic address:
Background: Due to the global growth of its prevalence and its impact on patient health, obesity is considered a near-epidemic condition by the World Health Organization (WHO). Its overall prevalence has now reached 17 % in France. The impact of obesity is also a concern for pregnant women, due to the risk of maternal and fetal complications.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!