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Weekly administration of betulinic acid prevents development of chronic renal failure from acute renal failure in folic acid-induced mouse model of kidney injury.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, 243 122, India.
Betulinic acid (BA) has been shown to exhibit various pharmacological activities and it has shown the protective effect on acute renal failure (ARF) and chronic renal failure (CRF); however, no reports are available on its effect on ARF-CRF transition. Therefore, we aimed to investigate the effects of BA on ARF-CRF transition. A single dose of 250 mg/kg body weight (BW) intraperitoneal injection of folic acid was given in mice for inducing ARF-CRF transition (injury group; I) on day 1.
View Article and Find Full Text PDFProtective effect of compound K against podocyte injury in chronic kidney disease by maintaining mitochondrial homeostasis.
Sci Rep
January 2025
The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
Chronic kidney disease (CKD) stands as a formidable global health challenge, often advancing to end-stage renal disease (ESRD) with devastating morbidity and mortality. At the central of this progression lies podocyte injury, a critical determinant of glomerular dysfunction. Compound K (CK), a bioactive metabolite derived from ginsenoside, has emerged as a compelling candidate for nephroprotective therapy.
View Article and Find Full Text PDFThe DNA demethylase TET1 modifies the impact of maternal folic acid status on embryonic brain development.
EMBO Rep
January 2025
Department of Development and Regeneration, Stem Cell and Developmental Biology, KU Leuven, Leuven, 3000, Belgium.
Folic acid (FA) is well known to prevent neural tube defects (NTDs), but we do not know why many human NTD cases still remain refractory to FA supplementation. Here, we investigate how the DNA demethylase TET1 interacts with maternal FA status to regulate mouse embryonic brain development. We determined that cranial NTDs display higher penetrance in non-inbred than in inbred Tet1 embryos and are resistant to FA supplementation across strains.
View Article and Find Full Text PDFCombatting melioidosis with chemical synthetic lethality.
Proc Natl Acad Sci U S A
November 2024
Department of Molecular Biology, Princeton University, Princeton, NJ 08544.
has emerged as a nonpathogenic surrogate for , the causative agent of melioidosis, and an important Gram-negative model bacterium for studying the biosynthesis and regulation of secondary metabolism. We recently reported that subinhibitory concentrations of trimethoprim induce vast changes in both the primary and secondary metabolome of . In the current work, we show that the folate biosynthetic enzyme FolE2 is permissive under standard growth conditions but essential for in the presence of subinhibitory doses of trimethoprim.
View Article and Find Full Text PDFMTHFR C677T、MTHFR A1298C、MTRR A66G and MTR A2756G polymorphisms and male infertility risk: a systematic review and meta-analysis.
Reprod Biol Endocrinol
October 2024
Baoding No.1, Central Hospital, Baoding, Hebei Province, 071000, China.
Background: Epidemiological studies have reported that polymorphisms of folate-metabolizing genes have a significant impact on male infertility. However, the results of published studies have come to different conclusions.
Objective: To determine an association between folate-metabolizing gene polymorphisms and the risk of male infertility.
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