To investigate the peculiarities of surgical anatomy of superior and mid-thoracic portions of the thoracic duct, 70 human corpses of adults of both sexes were studied using modern anatomical and experimental methods. Some regularities of the changes of syntopy of the mediastinal organs and vessels and the connection of these changes with the individual features of thoracic structure are described. The relation between these peculiarities with the quantitative parameters of surgical procedures performed in superior and mid-thoracic portions of the thoracic duct is demonstrated.

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