Amalgam-contact hypersensitivity lesions and oral lichen planus.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod

Department of Dental Diagnostic Science, University of Texas Health Science Center San Antonio, 78229-3900, USA.

Published: March 2003

AI Article Synopsis

  • The study aimed to explore the link between amalgam dental fillings and oral lichen planus (OLP).
  • Researchers examined 81 patients with oral lichenoid lesions, identifying two main patient groups based on reactions to amalgam.
  • Results showed that patients with probable amalgam-contact hypersensitivity lesions (ACHLs) saw significant improvement after replacing amalgam fillings, while those with OLP without such hypersensitivity did not experience similar benefits.
  • The findings suggest that specific ACHLs can be positively influenced by amalgam replacement, highlighting a distinct subgroup within the broader OLP diagnosis.

Article Abstract

Objective: The purpose of this study was to investigate the relationship between amalgam restorations and oral lichen planus.

Study Design: Eighty-one patients with oral lichenoid lesions were characterized clinically and skin patch tested for amalgam or mercury hypersensitivity. Thirty-three of these patients had amalgam fillings in contact with oral lesions replaced and were followed to determine the outcome.

Results: Clinically, 2 patient groups were identified: (1) 30 patients with probable amalgam-contact hypersensitivity lesions (ACHLs) and (2) 51 patients with oral lichen planus (OLP) but no clear relationship with amalgam. Seventy percent of ACHL cases were patch test positive for amalgam or mercury compared with only 3.9% of OLP cases (P < .0001). Amalgam replacement resulted in lesion improvement in 93% of ACHL cases. No such improvement was observed in the OLP cases treated (P < .001).

Conclusion: OLP is a heterogeneous condition within which an ACHL subgroup can be identified. ACHLs, but not other OLP lesions, respond favorably to amalgam replacement. A strong clinical association between lesions and amalgam restorations plus a positive patch test result was a good predictor of lesion improvement on amalgam replacement.

Download full-text PDF

Source
http://dx.doi.org/10.1067/moe.2003.115DOI Listing

Publication Analysis

Top Keywords

oral lichen
12
amalgam replacement
12
amalgam
9
amalgam-contact hypersensitivity
8
hypersensitivity lesions
8
lichen planus
8
relationship amalgam
8
amalgam restorations
8
patients oral
8
amalgam mercury
8

Similar Publications

Oral cancer (OC) is a disease with poor prognosis mainly due to late diagnosis. There is considerable interest in the use and development of rapid, point of care (POC) non-invasive methods that can accelerate the diagnostic process. Bioimpedance (BI) is resistance to the passage of electric currents through tissue that reflects structural changes in the tissue.

View Article and Find Full Text PDF

There are no good evidence-based recommendations for any systemic treatment of erosive lichen planus (ELP). Extracorporeal photopheresis (ECP) may be an effective therapy for recalcitrant forms of the disease. We report 3 patients with severe ELP treated with ECP.

View Article and Find Full Text PDF

MAIT cells modulating the oral lichen planus immune microenvironment: a cellular crosstalk perspective.

Inflamm Res

January 2025

Departments of Oral Medicine, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong Province, China.

Mucosal-associated invariant T (MAIT) cells, a type of T lymphocytes with innate-like characteristics, are crucial in bridging innate and adaptive immunity. When activated, MAIT cells release various inflammatory molecules and swiftly respond to antigens. Notably, numerous studies highlight the significant impact of MAIT cells on tumors and various immune disorders by influencing the immune microenvironment.

View Article and Find Full Text PDF

Objectives: The aim of our study was to compare the salivary interleukin-6 (IL-6) concentration and the quality of life (QoL) in patients with oral lichen planus (OLP) or burning mouth syndrome (BMS).

Materials And Methods: A total of 160 subjects participated in the cross-sectional study. The unstimulated whole saliva (UWS) was used as a reference for the determination of salivary IL-6 concentration by enzyme-linked immunosorbent assays (ELISAs).

View Article and Find Full Text PDF

Objective: To compare the demographic and clinical profiles of oral lichen planus (OLP) and oral lichenoid lesions (OLL) diagnosed at a reference center in Southern Brazil from 2010 to 2019.

Methods: This retrospective study included 117 cases of suspected OLP submitted for biopsy. Investigated variables comprised sociodemographic profiles, medical history, harmful habits, clinical characteristics, and histopathological features.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!