Objective: The purpose of this study was to investigate the relationship between amalgam restorations and oral lichen planus.
Study Design: Eighty-one patients with oral lichenoid lesions were characterized clinically and skin patch tested for amalgam or mercury hypersensitivity. Thirty-three of these patients had amalgam fillings in contact with oral lesions replaced and were followed to determine the outcome.
Results: Clinically, 2 patient groups were identified: (1) 30 patients with probable amalgam-contact hypersensitivity lesions (ACHLs) and (2) 51 patients with oral lichen planus (OLP) but no clear relationship with amalgam. Seventy percent of ACHL cases were patch test positive for amalgam or mercury compared with only 3.9% of OLP cases (P < .0001). Amalgam replacement resulted in lesion improvement in 93% of ACHL cases. No such improvement was observed in the OLP cases treated (P < .001).
Conclusion: OLP is a heterogeneous condition within which an ACHL subgroup can be identified. ACHLs, but not other OLP lesions, respond favorably to amalgam replacement. A strong clinical association between lesions and amalgam restorations plus a positive patch test result was a good predictor of lesion improvement on amalgam replacement.
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http://dx.doi.org/10.1067/moe.2003.115 | DOI Listing |
Diagnostics (Basel)
December 2024
Department of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Oral cancer (OC) is a disease with poor prognosis mainly due to late diagnosis. There is considerable interest in the use and development of rapid, point of care (POC) non-invasive methods that can accelerate the diagnostic process. Bioimpedance (BI) is resistance to the passage of electric currents through tissue that reflects structural changes in the tissue.
View Article and Find Full Text PDFThere are no good evidence-based recommendations for any systemic treatment of erosive lichen planus (ELP). Extracorporeal photopheresis (ECP) may be an effective therapy for recalcitrant forms of the disease. We report 3 patients with severe ELP treated with ECP.
View Article and Find Full Text PDFInflamm Res
January 2025
Departments of Oral Medicine, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong Province, China.
Mucosal-associated invariant T (MAIT) cells, a type of T lymphocytes with innate-like characteristics, are crucial in bridging innate and adaptive immunity. When activated, MAIT cells release various inflammatory molecules and swiftly respond to antigens. Notably, numerous studies highlight the significant impact of MAIT cells on tumors and various immune disorders by influencing the immune microenvironment.
View Article and Find Full Text PDFOral Dis
January 2025
Department of Medical Laboratory Diagnostics, University Hospital of Split, Split, Croatia.
Objectives: The aim of our study was to compare the salivary interleukin-6 (IL-6) concentration and the quality of life (QoL) in patients with oral lichen planus (OLP) or burning mouth syndrome (BMS).
Materials And Methods: A total of 160 subjects participated in the cross-sectional study. The unstimulated whole saliva (UWS) was used as a reference for the determination of salivary IL-6 concentration by enzyme-linked immunosorbent assays (ELISAs).
Oral Dis
January 2025
Department of Oral Medicine, Otorhinolaryngology Service, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil.
Objective: To compare the demographic and clinical profiles of oral lichen planus (OLP) and oral lichenoid lesions (OLL) diagnosed at a reference center in Southern Brazil from 2010 to 2019.
Methods: This retrospective study included 117 cases of suspected OLP submitted for biopsy. Investigated variables comprised sociodemographic profiles, medical history, harmful habits, clinical characteristics, and histopathological features.
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