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Application of cold atmospheric plasma for decontamination of toxigenic fungi and mycotoxins: a systematic review.
Front Microbiol
January 2025
Laboratory of Food Microbiology and Mycotoxicology, Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, Brazil.
Introduction: Microbial contamination remains a vital challenge across the food production chain, particularly due to mycotoxins-secondary metabolites produced by several genera of fungi such as , and . These toxins, including aflatoxins, fumonisins, ochratoxins, and trichothecenes (nivalenol, deoxynivalenol, T2, HT-2). These contaminants pose severe risks to human and animal health, with their potential to produce a variety of different toxic effects.
View Article and Find Full Text PDFAFB1 consolidates HBV harm to induce liver injury and carcinogenic risk by inactivating FTCD-AS1-PXR-MASP1 axis.
Toxicology
January 2025
Department of Pharmacology, Shantou University Medical College, Shantou 515041, China. Electronic address:
Aflatoxin B1 (AFB1) has been reported to synergize with hepatitis B virus (HBV) to induce development of hepatocellular carcinoma (HCC). Precise daily exposure to AFB1 and its contribution to liver injury have not been quantified and have even been disregarded due to lack of convenient detection, and the strong species specificity of HBV infection has restricted research on their synergistic harm. Hence, our objective was to investigate the molecular mechanisms by which AFB1 exacerbates HBV-related injury.
View Article and Find Full Text PDFThe Detoxification Effects of Melatonin on Aflatoxin-Caused Toxic Effects and Underlying Molecular Mechanisms.
Antioxidants (Basel)
December 2024
National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Aflatoxins (AFTs) are a form of mycotoxins mainly produced by and , which are common contaminants in various agricultural sources such as feed, milk, food, and grain crops. Aflatoxin B1 (AFB1) is the most toxic one among all AFTs. AFB1 undergoes bioactivation into AFB1-8,9-epoxide, then leads to diverse harmful effects such as neurotoxicity, carcinogenicity, hepatotoxicity, reproductive toxicity, nephrotoxicity, and immunotoxicity, with specific molecular mechanisms varying in different pathologies.
View Article and Find Full Text PDFWhole-exome sequencing reveals genomic landscape of intrahepatic cholangiocarcinoma and identifies SAV1 as a potential driver.
Nat Commun
November 2024
Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai, China.
Article Synopsis
- - Intrahepatic cholangiocarcinoma (ICC) is the second most common liver cancer, with a poor prognosis and few treatment options, especially among Chinese patients whose genomic features are not well understood.
- - This study analyzes the whole-exome sequencing of 204 ICC samples from Chinese patients, identifying six mutational signatures, including those linked to known harmful substances, and 13 significantly mutated genes such as SAV1.
- - Researchers found that mutations in the SAV1 gene are linked to lower protein levels, increased tumor recurrence, and shorter patient survival, suggesting it plays a tumor-suppressor role that impacts cancer progression through Hippo signaling pathways.
Evaluation of Ability of Inactivated Biomasses of and to Adsorb Aflatoxin B In Vitro.
Foods
October 2024
Departamento de Engenharia de Alimentos, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga 13635-900, SP, Brazil.
Biological decontamination strategies using microorganisms to adsorb aflatoxins have shown promising results for reducing the dietary exposure to these contaminants. In this study, the ability of inactivated biomasses of (LRB) and (SCB) incorporated alone or in combination into functional yogurts (FY) at 0.5-4.
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