Violent activity in the nuclei of galaxies has long been considered a curiosity in its own right; manifestations of this phenomenon include distant quasars in the early Universe and comparatively nearby Seyfert galaxies, both thought to be powered by the release of gravitational potential energy as material from the host galaxy accretes onto a central supermassive black hole (SMBH). Traditionally, the broader study of the formation, structure and evolution of galaxies has largely excluded active galactic nuclei. Recently, however, this situation has changed dramatically, both observationally and theoretically, with the realization that the growth and influence of the SMBH, the origin and development of galaxies and nuclear activity at different epochs in the Universe may be intimately related. The most spectacular fireworks seen in distant quasars may be relatively easy to explain, since the era of greatest quasar activity seems to coincide with turbulent dynamics at the epoch of galaxy formation in the young, gas-rich Universe. Ubiquitous black holes are believed to be a legacy of this violent birth. Alternatively, black holes may be the seeds that drive galaxy formation in the first place. Closer to home, and hence more recently in the history of the Universe, a fraction of comparatively ordinary galaxies, similar to our own, has reignited their central engines, albeit at a lower level of activity. Since these galaxies are more established than their younger and more distant counterparts, the activity here is all the more puzzling. Whatever the mechanisms involved, they are likely to play an important role in galaxy evolution. I review the intriguing evidence for causal links between SMBHs, nuclear activity and the formation and evolution of galaxies, and describe opportunities for testing these relationships using the next generation of earthbound and space-borne astronomical facilities.
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http://dx.doi.org/10.1098/rsta.2002.1058 | DOI Listing |
Sci Rep
January 2025
Colloid Chemistry, Department of Chemistry, University of Konstanz, Universitaetsstrasse 10, 78464, Konstanz, Germany.
Complex structures can be understood as compositions of smaller, more basic elements. The characterization of these structures requires an analysis of their constituents and their spatial configuration. Examples can be found in systems as diverse as galaxies, alloys, living tissues, cells, and even nanoparticles.
View Article and Find Full Text PDFNat Geosci
December 2024
Université Paris Cité, Institut de Physique du Globe de Paris, CNRS, Paris, France.
Saturn's rings have been estimated to be as young as about 100 to 400 million years old according to the hypothesis that non-icy micrometeoroid bombardment acts to darken the rings over time and the Cassini observation indicated that the ring particles appear to be relatively clean. These young age estimates assume that the rings formed out of pure water ice particles with a high accretion efficiency of impacting non-icy micrometeoroid material ( ≳ 10%). Here we show, using numerical simulations of hypervelocity micrometeoroid impacts on a ring particle, that non-icy material may not be as readily accreted as previously thought.
View Article and Find Full Text PDFDrugs Real World Outcomes
January 2025
Department of Medical Affairs, Cipla Ltd., Mumbai Central, Mumbai, Maharashtra, 400008, India.
Background And Objective: Vildagliptin sustained release (XR), a formulation that provides vildagliptin 100 mg with a once-daily dose administration, is a recent introduction to manage type 2 diabetes mellitus in India. This study aimed to evaluate the effectiveness and tolerability of vildagliptin XR in patients with type 2 diabetes in real-world clinical settings.
Methods: This was an observational, prospective, multicenter, cohort study conducted in India, which included patients with type 2 diabetes uncontrolled on metformin XR monotherapy with glycated hemoglobin (HbA1c) > 7.
Sens Diagn
December 2024
Department of Bioengineering, Rice University Houston TX 77030 USA
CRISPR-Cas-based lateral flow assays (LFAs) have emerged as a promising diagnostic tool for ultrasensitive detection of nucleic acids, offering improved speed, simplicity and cost-effectiveness compared to polymerase chain reaction (PCR)-based assays. However, visual interpretation of CRISPR-Cas-based LFA test results is prone to human error, potentially leading to false-positive or false-negative outcomes when analyzing test/control lines. To address this limitation, we have developed two neural network models: one based on a fully convolutional neural network and the other on a lightweight mobile-optimized neural network for automated interpretation of CRISPR-Cas-based LFA test results.
View Article and Find Full Text PDFBraz J Microbiol
January 2025
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, 05508-900, Brazil.
Despite meticulous precautions, contamination of genomic DNA samples is not uncommon, which can significantly compromise the analysis of microorganisms' whole-genome sequencing data, thus affecting all subsequent analyses. Thanks to advancements in software and bioinformatics techniques, it is now possible to address this issue and prevent the loss of the entire dataset obtained in a contaminated whole-genome sequencing, where the DNA of another bacterium is present. In this study, it was observed that the sequencing reads from Streptomyces sp.
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