Quetiapine is a medication approved for the treatment of psychotic disorders in adults. At this time it is not approved for the treatment of children or adolescents. It is an atypical antipsychotic agent that is efficacious in treating both the positive and negative symptoms of schizophrenia. There is currently little information available concerning the safety of quetiapine in overdose, and there are no previous case reports of quetiapine overdose in the pediatric population. We present the case of a 15-year-old girl who ingested 1250 mg of quetiapine (21.6 mg/kg) in a suicide attempt. She developed multiple symptoms including tachycardia, agitation, hypotension, and unconsciousness. We compare her symptoms to previous adult cases of quetiapine overdose and review overdose treatment recommendations. We also examine clinical situations that may lead to a more severe clinical course.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1089/104454602762599916 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neuroleptic Malignant Syndrome with Low-dose Quetiapine After Venlafaxine Withdrawal: A Case Report.
Turk Psikiyatri Derg
September 2024
Article Synopsis
- * A case report describes a 40-year-old man who developed NMS after withdrawing from venlafaxine while taking a low dose of quetiapine, suggesting that withdrawal may be a contributing factor in NMS cases.
- * This case highlights the importance of recognizing the risk of NMS even at low doses of quetiapine in patients without known risk factors, emphasizing the need for careful monitoring and prompt diagnosis.
Pharmacobezoar Associated Prolonged Clinical Course in a Patient with Immediate Release Quetiapine Overdose.
J Med Toxicol
October 2024
Department of Forensic Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8553, Japan.
Introduction: Quetiapine is available in both immediate-release (IR) and extended-release (XR) formulations. Quetiapine XR overdose is known to cause delayed increase in serum quetiapine concentrations. However, it is not certain whether quetiapine IR overdose would similarly cause a delayed increase in serum quetiapine concentrations.
View Article and Find Full Text PDFPharmacokinetic effects of endoscopic gastric decontamination for multidrug gastric pharmacobezoars.
Toxicol Rep
December 2024
Pediatric Intensive Care Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Introduction: Intentional multiple drugs overdose is an often-encountered method of self-harm in adolescence. Treatments include supportive therapy, antidotes (when available) and decontamination techniques with the aim of reducing drugs absorption by the gastrointestinal system to minimize toxicity. Nevertheless, the decontamination techniques currently used, such as gastric lavage (GL), activated charcoal or whole-bowel irrigation, have a questionable effectiveness.
View Article and Find Full Text PDFEffect of lipid emulsion on neuropsychiatric drug-induced toxicity: A narrative review.
Medicine (Baltimore)
March 2024
Department of Anesthesiology and Pain Medicine, Gyeongsang National University College of Medicine, Gyeongsang National University Hospital, Jinju-si, Republic of Korea.
Article Synopsis
- Lipid emulsion has been found to be effective in treating serious cardiovascular issues caused by toxic levels of certain neuropsychiatric drugs, particularly those that are lipophilic (fat-soluble).
- A study analyzed case reports to evaluate how lipid emulsions impacted patient recovery based on the Glasgow Coma Scale and corrected QT intervals, focusing on specific drugs like amitriptyline and trazodone.
- Results showed that 98.3% of patients improved with lipid emulsion treatment, although more research is necessary to fully understand its effects and optimize its use.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!