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Geroprotective effects of GdVO:Eu nanoparticles, metformin and calorie restriction in male rats with accelerated aging induced by overnutrition in early postnatal ontogenesis.
Biogerontology
November 2024
Karazin Kharkiv National University, Svobody Square, 4, Kharkiv, 61022, Ukraine.
GdVO:Eu nanoparticles (OVNPs) have previously been shown to exhibit anti-aging effects in old rats.The accelerated aging model (overnutrition in early postnatal ontogenesis (POF)) was used to confirm the effect of OVNPs as a potential geroprotector. A comparative study of the effect of OVNPs, calorierestriction (CR) and CR-mimetic-metformin was carried out using a number of criteria: survival, prooxidant-antioxidant balance in the liver and blood, physiological parameters of male Wistar rats with accelerated aging.
View Article and Find Full Text PDFAutophagy modulation attenuates sorafenib resistance in HCC induced in rats.
Cell Death Dis
August 2024
Biochemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Hepatocellular carcinoma (HCC) has risen as the villain of cancer-related death globally, with a usual cruel forecasting. Sorafenib was officially approved by the FDA as first-line treatment for advanced HCC. Despite the brilliant promise revealed in research, actual clinical results are limited due to the widespread appearance of drug resistance.
View Article and Find Full Text PDF1,3,4-Oxadiazole Scaffold in Antidiabetic Drug Discovery: An Overview.
Mini Rev Med Chem
October 2024
Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India.
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st century. With the increasing number of cases of diabetes and drug-resistant diabetes, there is an urgent need to develop new potent molecules capable of combating this cruel disease. Medicinal chemistry concerns the discovery, development, identification, and interpretation of the mode of action of biologically active compounds at the molecular level.
View Article and Find Full Text PDFHoneybee cluster-not insulation but stressful heat sink.
J R Soc Interface
November 2023
Institute of Thermofluids, School of Mechanical Engineering University of Leeds, Leeds, UK.
Since the early twentieth century, the outer layer (mantle) of honeybees () in the winter cluster has been said to insulate the cluster core. This has encouraged enforced clustering, by the beekeepers' dominant use of inadequately insulated hives and, in North America, refrigeration. This is often seen as a benign or even a necessary process, with beekeeping and academic research considering these conditions of extreme heat loss, compared with the honeybee's natural habitat, as natural and normal.
View Article and Find Full Text PDFFrom Cereal Grains to Immunochemistry-What Role Have Antibodies Played in the History of the Home Pregnancy Test.
Antibodies (Basel)
August 2023
Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, ul. Ujejskiego 75, 85-168 Bydgoszcz, Poland.
Today, the home pregnancy test is the most frequently performed laboratory test for self-diagnosis (home diagnostic test). It is also the first laboratory test that has been adapted for self-use at home. This is probably because women have always wanted to know the answer to the question: "Am I pregnant or not?" and always preferred to know the answer to this question intimately and in a discreet way.
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