Cytotoxic hydroazulene diterpenes from the brown alga Dictyota dichotoma.

Z Naturforsch C J Biosci

Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

Published: April 2003

Two new hydroazulenoid (prenyl guaiane) diterpenes, dictyone acetate (2) and 3,4-epoxy 13-hydroxy pachydictyol A (4) were isolated from the petroleum ether fraction of the alcoholic extract of the brown alga, Dictyota dichotoma (Hudson) Lamouroux, which was collected from the Red Sea coasts at Hurgada, Egypt, together with three known ones, pachydictyol A (1), dictyone (3) and 11-hydroxypachydictyol A (dictyol E) (5). In addition, the steroidal compound, stigmasta-5,(E)-24(28)-dien-3-beta-ol (fucosterol) (6) was also isolated. The structures of the isolated compounds have been determined on the basis of spectroscopic evidences as well as physical and chemical correlation with known compounds. Compounds 1, 2, 3 and 5 showed moderate cytotoxic activity.

Download full-text PDF

Source
http://dx.doi.org/10.1515/znc-2003-1-203DOI Listing

Publication Analysis

Top Keywords

brown alga
8
alga dictyota
8
dictyota dichotoma
8
cytotoxic hydroazulene
4
hydroazulene diterpenes
4
diterpenes brown
4
dichotoma hydroazulenoid
4
hydroazulenoid prenyl
4
prenyl guaiane
4
guaiane diterpenes
4

Similar Publications

In this study, we investigated the photoperiodic responses regulating erect thallus formation in (KU-1293). We found that, through critical day length analysis and night break treatment culture experiments, formed erect thalli under short-day conditions, indicating a genuine photoperiodic response. The critical day length for this morphological change was 10-11 h.

View Article and Find Full Text PDF

The fungal genus Fusarium is a treasure-trove of structurally diverse secondary metabolites, contributed greatly by marine-derived strains. A new cedrane sesquiterpene, fusacedrol (1), and a new fusarin member, fusarin M (2), were isolated from F. graminearum 12Ⅱ2N that was isolated as an endophyte from the marine brown alga Sargassum sp.

View Article and Find Full Text PDF

(), an edible brown alga, is rich in isophloroglucin A (IPA) phlorotannin compounds and is effective in preventing diseases, including diabetes. We evaluated its anti-glycation ability, intracellular reactive oxygen species scavenging activity, inhibitory effect on the accumulation of intracellular MGO/MGO-derived advanced glycation end products (AGE), and regulation of downstream signaling pathways related to the AGE-receptor for AGEs (RAGE) interaction. IPA (0.

View Article and Find Full Text PDF

The optimization of bioactive compound extraction from using ultrasound-assisted extraction (UAE) via sonotrode was investigated to maximize phenolic recovery and antioxidant activity while promoting a sustainable process. Optimal conditions (40% / ethanol in water, 38 min, 36% amplitude) were selected to maximize phenolic recovery while considering environmental and energy sustainability by optimizing extraction efficiency and minimizing solvent and energy usage. HPLC-ESI-QTOF-MS analysis tentatively identified 25 phenolic compounds, including sulfated phenolic acids, phlorotannins, flavonoids, and halophenols, with some reported for the first time in , underscoring the complexity of this alga's metabolome.

View Article and Find Full Text PDF

The effect of the in vitro acute exposure to diesel oil (0.001%, 0.01%, 0.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!