In Vienna/Austria, with leading representatives of the so-called second Viennese medical school at the turn of the 19th to the 20th century, the detection of x-rays by W. C. Röntgen was observed with special interest. In the general hospital of Vienna, where still today the medical school of the university of Vienna is hosted, high research activities to understand the origin and the effects of X-rays were performed. Guido Holzknecht (1872-1931) was the first chairman of the central roentgen laboratory. Today, the scientific and the clinical activities at the department of diagnostic radiology are manifold and virtually all fields of imaging are covered.
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Proc Natl Acad Sci U S A
January 2025
Computational Radiology Laboratory, Boston Children's Hospital, Boston, MA 02115.
This study presents the construction of a comprehensive spatiotemporal atlas of white matter tracts in the fetal brain for every gestational week between 23 and 36 wk using diffusion MRI (dMRI). Our research leverages data collected from fetal MRI scans, capturing the dynamic changes in the brain's architecture and microstructure during this critical period. The atlas includes 60 distinct white matter tracts, including commissural, projection, and association fibers.
View Article and Find Full Text PDFNucleic Acids Res
December 2024
Department Laboratory Medicine, Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands.
In recent years, pathogenic variants in ARS genes, encoding aminoacyl-tRNA synthetases (aaRSs), have been associated with human disease. Patients harbouring pathogenic variants in ARS genes have clinical signs partly unique to certain aaRSs defects, partly overlapping between the different aaRSs defects. Diagnosis relies mostly on genetics and remains challenging, often requiring functional validation of new ARS variants.
View Article and Find Full Text PDFNucleic Acids Res
December 2024
Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Munich, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
RNA-binding proteins are essential for gene regulation and the spatial organization of cells. Here, we report that the yeast ribosome biogenesis factor Loc1p is an intrinsically disordered RNA-binding protein with eight repeating positively charged, unstructured nucleic acid binding (PUN) motifs. While a single of these previously undefined motifs stabilizes folded RNAs, multiple copies strongly cooperate to catalyze RNA folding.
View Article and Find Full Text PDFRadiol Imaging Cancer
November 2024
From the Department of Radiology, Division of Abdominal Imaging (B.V., T.P.) and Gillette Center for Women's Cancers (A.B., A.M.), Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114.
ACS Infect Dis
October 2024
UMR7042 CNRS-Unistra-UHA, Laboratoire d'Innovation Moléculaire et Applications (LIMA), Bio(in)organic & Medicinal Chemistry Team, European School of Chemistry, Polymers and Materials (ECPM), 25, Rue Becquerel, Strasbourg F-67087, France.
The apicoplast is an essential organelle for the viability of apicomplexan parasites or , which has been proposed as a suitable drug target for the development of new antiplasmodial drug-candidates. Plasmodione, an antimalarial redox-active lead drug is active at low nM concentrations on several blood stages of such as early rings and gametocytes. Nevertheless, its precise biological targets remain unknown.
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