The synthesis of 14S pentamers and 70S empty capsids of hepatitis A virus (HAV) has been accomplished by expressing the viral genome for periods of time longer than 4 h in Escherichia coli. HAV pentamers (14S) self-assembled into capsids (70S) in vitro. The antibodies induced by these structures recognized and neutralized HAV.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150110 | PMC |
| http://dx.doi.org/10.1128/AEM.69.3.1840-1843.2003 | DOI Listing |
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