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What is the Role of Measuring Urinary Gluten Immunogenic Peptides in Clinical Practice in Patients with Coeliac Disease?
J Gastrointestin Liver Dis
December 2024
Academic Unit of Gastroenterology, Sheffield Teaching Hospitals National Health Service Foundation Trust, Sheffield; Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.
Background And Aims: In coeliac disease, the clinical role of the urinary gluten immunogenic peptide is unclear. It has been suggested it can be a non-invasive marker of villous atrophy. Therefore, we present the largest cross-sectional clinical data in patients with coeliac disease to establish the diagnostic accuracy of the urinary gluten immunogenic peptide in identifying villous atrophy.
View Article and Find Full Text PDFAn Unusual Case of Nephrotic Range Proteinuria in a Short-Standing Type 1 Diabetic Patient with Newly Diagnosed Systemic Lupus Erythematosus: A Case Report and Literature Review.
Med Sci (Basel)
December 2024
Department of Nephrology, Hospital Cayetano Heredia, Lima 15002, Peru.
Background: Lupus podocytopathy (LP) is a non-immune complex-mediated glomerular lesion in systemic lupus erythematosus (SLE), characterized by the diffuse effacement of podocyte processes without immune complex deposition or with only mesangial immune complex deposition. LP is a rare cause of nephrotic syndrome in SLE patients with implications for prognosis and treatment.
Case Report: We present the case of a 28-year-old woman with a medical history of type 1 diabetes mellitus (T1DM) who presented with lower limb edema, dyspnea, hypercholesterolemia, with nephrotic range proteinuria, without acute kidney injury, and laboratory findings compatible with auto-immune hemolytic anemia.
Slit skin smear versus anti-phenolic glycolipid-I serology in diagnosis of leprosy: a cross sectional study.
Arch Dermatol Res
December 2024
Department of Dermatology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.
Leprosy is a chronic infectious disease which mainly affects the skin, nasal mucosa, and peripheral nerves. The aim of this study was to compare between the efficacies of serum anti-phenolic glycolipid 1 (APGL-I) level versus slit skin smear (SSS) in diagnosis of leprosy. This study involved 58 leprosy cases who were clinically examined, slit-skin smears were taken from all at diagnosis from four sites and APGL-I levels were seroassayed using ELISA.
View Article and Find Full Text PDFDisseminated histoplasmosis and presumptive CNS toxoplasmosis-associated immune reconstitution inflammatory syndrome in a patient with HIV/AIDS: a case report.
BMC Infect Dis
December 2024
Division of Infectious Diseases, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Article Synopsis
- A 55-year-old woman with HIV/AIDS, adhering to her antiretroviral therapy, was hospitalized due to swallowing difficulties and swollen lymph nodes, revealing a rare case of disseminated histoplasmosis and suspected cerebral toxoplasmosis.
- The diagnosis was confirmed through various tests, including a biopsy, (1-3) -β-glucan assay, and imaging studies.
- This case underscores the challenges of managing opportunistic infections during immune recovery in HIV patients and the importance of vigilant monitoring and comprehensive diagnostics.
The feasibility of using a multivariate regression model incorporating ultrasound findings and serum markers to predict thyroid cancer metastasis.
Front Endocrinol (Lausanne)
December 2024
Department of Ultrasound, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Article Synopsis
- The study evaluated a multivariate regression model that uses ultrasound findings and serum markers to predict thyroid cancer metastasis among 98 patients.
- It categorized patients into two groups: those with metastasis (20 patients) and without (78 patients), and examined various indicators for their predictive value.
- Results showed that a combination of ultrasound signs and serum markers significantly improved prediction accuracy, highlighting the model's potential for enhancing early detection and intervention in thyroid cancer cases.
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