A series of bicyclic pyrimidinone-based HCV NS3 protease inhibitors was synthesized via selective C8 position functionalization. Substituted phenylamides and phenylureas were preferred in the S2 binding pocket.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0960-894x(03)00022-2 | DOI Listing |
Publication Analysis
Top Keywords
bicyclic pyrimidinone-based
8
pyrimidinone-based hcv
8
hcv ns3
8
ns3 protease
8
protease inhibitors
8
design synthesis
4
synthesis bicyclic
4
inhibitors series
4
series bicyclic
4
inhibitors synthesized
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!