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Objectives: CD5+ B cells are phenotypically and functionally distinct from the conventional (CD5-) B cells, and the function of CD5+ B cells in the upper respiratory tract remains unknown. A previous study showed that immunoglobulin A-producing cells in the adenoid play a protective role in the nasopharynx. In the present study, the contribution of adenoid CD5+ B cells to nasopharyngeal immunity at the single cell level was investigated.
Study Design: In vitro laboratory study.
Methods: Mononuclear cells were isolated from adenoids of children aged 1 to 12 years, and the frequency of CD5+ B cells was determined by flow cytometry. The numbers of cells producing immunoglobulin M, immunoglobulin G, and immunoglobulin A in sorted adenoid CD5+ B cells were determined by enzyme-linked immunospot assay. Further, to characterize adenoid CD5+ B cells, the expression of various surface molecules was analyzed by flow cytometry.
Results: The results showed that adenoids of young children contain a relatively large number of CD5+ B cells, which have a greater capacity for antibody production than do CD5- B cells. CD5+ B cells also differed from CD5- B cells in the expression of interleukin receptors Il-4R, IL-5R, and IL-10R as well as CD27, B7-1, B7-2, Fas, and Bcl-2.
Conclusions: These findings suggest that adenoid CD5+ B cells contribute to protective immunity by forming a first line of defense in the upper respiratory tract of young children and that they are probably regulated in a manner that differs from that of CD5- B cells.
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| http://dx.doi.org/10.1097/00005537-200303000-00017 | DOI Listing |
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