Objective: Protein S (PS) is a component of the protein C anticoagulant system. PS deficiency is associated with myocardial infarction and venous thromboembolism, two highly prevalent causes of death in industrialized nations. As part of the Genetic Analysis of Idiopathic Thrombophilia (GAIT) project, we conducted a genome-wide linkage screen to localize genes influencing variation in free PS (fPS) plasma levels.
Methods And Results: fPS levels were measured in 397 individuals in 21 Spanish families. A total of 363 highly informative microsatellite markers were genotyped to provide a 10-cM genetic map, and variance component linkage methods were used. A region on chromosome 1q32, flanked by markers D1S425 and D1S213, showed strong evidence of linkage with fPS levels (LOD score, 4.07; nominal P=7.5x10(-6); genome-wide P=0.0024). This region contains two positional candidate genes, the complement component 4-binding protein alpha and beta chains, which encode the principal binding protein for PS. Suggestive evidence for linkage was also observed on chromosomes 11p and 19p.
Conclusions: These results represent one of the first genomic screens for quantitative variation in a component of the hemostatic pathway and provide strong evidence for a locus on chromosome 1q influencing fPS levels.
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http://dx.doi.org/10.1161/01.ATV.0000055740.22563.C5 | DOI Listing |
Front Plant Sci
December 2024
The Key Laboratory for Crop Production and Smart Agriculture of Yunnan Province, Yunnan Agricultural University, Kunming, Yunnan, China.
Tea leaf diseases are significant causes of reduced quality and yield in tea production. In the Yunnan region, where the climate is suitable for tea cultivation, tea leaf diseases are small, scattered, and vary in scale, making their detection challenging due to complex backgrounds and issues such as occlusion, overlap, and lighting variations. Existing object detection models often struggle to achieve high accuracy in detecting tea leaf diseases.
View Article and Find Full Text PDFSensors (Basel)
November 2024
College of Engineering Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
The removal of back armor marks the first stage in the comprehensive processing of river crabs. However, the current low level of mechanization undermines the effectiveness of this process. By integrating robotic systems with image recognition technology, the efficient removal of dorsal armor from river crabs is anticipated.
View Article and Find Full Text PDFSensors (Basel)
November 2024
Artificial Intelligence and Robotics Lab (AIRLab), Department of Computer Science, Saint Louis University, Saint Louis, MO 63103, USA.
In this paper, we present , the first successful application of neuromorphic for Wide-Area Motion Imagery (WAMI) and Remote Sensing (RS), showcasing their potential for advancing Structure-from-Motion (SfM) and 3D reconstruction across diverse imaging scenarios. ECs, which detect asynchronous pixel-level , offer key advantages over traditional frame-based sensors such as high temporal resolution, low power consumption, and resilience to dynamic lighting. These capabilities allow ECs to overcome challenges such as glare, uneven lighting, and low-light conditions that are common in aerial imaging and remote sensing, while also extending UAV flight endurance.
View Article and Find Full Text PDFBiomed Opt Express
December 2024
Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA.
We explore camera-based pupil tracking using high-level programming in computing platforms with end-user discrete and integrated central processing units (CPUs) and graphics processing units (GPUs), seeking low calculation latencies previously achieved with specialized hardware and programming (Kowalski et al., [Biomed. Opt.
View Article and Find Full Text PDFKnee Surg Sports Traumatol Arthrosc
December 2024
Department of Orthopaedic Surgery and Traumatology, Hospital and University of Fribourg, Fribourg, Switzerland.
Purpose: In modern anterior cruciate ligament (ACL) surgery, the focus is usually on anatomical reconstruction to restore the natural kinematics of the knee. The individual optimal positioning of the ACL footprints (FPs) in primary surgery is still controversial and, especially in revision surgery, difficult to realize surgically. In this regard, a new MRI-based sequence, the Compressed Lateral and anteroposterior Anatomic Systematic Sequence (CLASS) with marked femoral and tibial FPs as a template, could help.
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