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A Dual-Channel and Frequency-Aware Approach for Lightweight Video Instance Segmentation.
Sensors (Basel)
January 2025
The Higher Educational Key Laboratory for Measuring & Control Technology and Instrumentation of Heilongjiang Province, Harbin University of Science and Technology, Harbin 150080, China.
Video instance segmentation, a key technology for intelligent sensing in visual perception, plays a key role in automated surveillance, robotics, and smart cities. These scenarios rely on real-time and efficient target-tracking capabilities for accurate perception and intelligent analysis of dynamic environments. However, traditional video instance segmentation methods face complex models, high computational overheads, and slow segmentation speeds in time-series feature extraction, especially in resource-constrained environments.
View Article and Find Full Text PDFMulti-Structure-Based Refractive Index Sensor and Its Application in Temperature Sensing.
Sensors (Basel)
January 2025
School of Electrical Engineering, Zhejiang University of Water Resources and Electric Power, Hangzhou 310018, China.
In this paper, a new sensor structure is designed, which consists of a metal-insulator-metal (MIM) waveguide and a circular protrusion and a rectangular triangular cavity (CPRTC). The characterization of nanoscale sensors is considered using an approximate numerical method (finite element method). The simulation results show that the sharp asymmetric resonance generated by the interaction between the discrete narrow-band mode and the continuous wideband mode is called Fano resonance.
View Article and Find Full Text PDFEnhancing HDAC Inhibitor Screening: Addressing Zinc Parameterization and Ligand Protonation in Docking Studies.
Int J Mol Sci
January 2025
Department of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
Precise binding free-energy predictions for ligands targeting metalloproteins, especially zinc-containing histone deacetylase (HDAC) enzymes, require specialized computational approaches due to the unique interactions at metal-binding sites. This study evaluates a docking algorithm optimized for zinc coordination to determine whether it could accurately differentiate between protonated and deprotonated states of hydroxamic acid ligands, a key functional group in HDAC inhibitors (HDACi). By systematically analyzing both protonation states, we sought to identify which state produces docking poses and binding energy estimates most closely aligned with experimental values.
View Article and Find Full Text PDFInsights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy.
Biomolecules
December 2024
Laboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Hajdrihova 19, p.p. 660, SI-1001 Ljubljana, Slovenia.
Human heat shock protein 90 (Hsp90) is one of the most important chaperones that play a role in the late stages of protein folding. Errors in the process of the chaperone cycle can lead to diseases such as cancer and neurodegenerative diseases. Therefore, the activity of Hsp90 must be carefully regulated.
View Article and Find Full Text PDFAcetohydroxyacid Synthase (AHAS) inhibitors as Antitubercular agents: Insights from Molecular Docking and Dynamics Simulations.
Chem Biodivers
January 2025
NMIMS Deemed to be University - Mumbai Campus: NMIMS, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SPPSPTM, VILE PARLE WEST, 400056, Mumbai, INDIA.
Acetohydroxyacid synthase (AHAS) is a vital enzyme in Mycobacterium tuberculosis, the pathogen causing tuberculosis (TB), involved in branched-chain amino acid synthesis. Targeting AHAS for drug design against TB offers a promising strategy due to its essentiality in bacterial growth. In current investigation, we have designed 160 novel compounds by leveraging key scaffolds identified through structure-based drug design (SBDD) methodologies.
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