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A Novel, Site-Specific N-Linked Glycosylation Model Provides Mechanistic Insights Into the Process-Condition Dependent Distinct Fab and Fc Glycosylation of an IgG1 Monoclonal Antibody Produced by CHO VRC01 Cells.
Biotechnol Bioeng
December 2024
Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA.
The CHO VRC01 cell line produces an anti-HIV IgG1 monoclonal antibody containing N-linked glycans on both the Fab (variable) and Fc (constant) regions. Site-specific glycan analysis was used to measure the complex effects of cell culture process conditions on Fab and Fc glycosylation. Experimental data revealed major differences in glycan fractions across the two sites.
View Article and Find Full Text PDFInvestigation of ritonavir analogs antiretroviral natural compounds against SARS-CoV-2 envelope protein.
J Biomol Struct Dyn
February 2025
Department of Physics, DDU Gorakhpur University, Gorakhpur, Uttar Pradesh, India.
Since the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported from Wuhan, China, there has been a surge in scientific research to find a permanent cure for the disease. The main challenge in effective drug discovery is the continuously mutating nature of the SARS-CoV-2 virus. Thus, we have used the I-TASSER modeling to predict the structure of the SARS-CoV-2 viral envelope protein followed by combinatorial computational assessment to predict its putative potential small molecule inhibitors.
View Article and Find Full Text PDFPredictions to Increase Lasso Peptide Production in the Heterologous Host Streptomyces coelicolor M1152.
Biotechnol Bioeng
December 2024
Centre for Biotechnology and Bioengineering (CeBiB), Department of Chemical Engineering, Biotechnology and Materials, University of Chile, Santiago, Chile.
Production of specialized metabolites are restricted to the metabolic capabilities of the organisms. Genome-scale models (GEM)s are useful to study the whole metabolism and to find metabolic engineering targets to increase the yield of a target compound. In this work we use a modified model of Streptomyces coelicolor M145 to simulate the production of lagmysin A (LP4) and the novel lagmysin B (LP2) lasso peptide, in the heterologous host Streptomyces coelicolor M1152.
View Article and Find Full Text PDFCFD-Based Determination of Optimal Design and Operating Conditions of a Fermentation Reactor Using Bayesian Optimization.
Biotechnol Bioeng
December 2024
Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California, USA.
The efficiency of fermentation reactors is significantly impacted by gas dispersion and concentration distribution, which are influenced by the reactor's design and operating conditions. As the process scales up, optimizing these parameters becomes crucial due to the pronounced concentration gradients that can arise. This study integrates the kinetics of the fermentation process with hydrodynamic analysis using Bayesian optimization to efficiently determine the optimal reactor design and operating conditions.
View Article and Find Full Text PDFH Consumption by Various Acetogenic Bacteria Follows First-Order Kinetics up to H Saturation.
Biotechnol Bioeng
December 2024
Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.
Acetogenic bacteria play an important role in various biotechnological processes, because of their chemolithoautotrophic metabolism converting carbon dioxide with molecular hydrogen (H) as electron donor into acetate. As the main factor limiting acetogenesis is often H, insights into the H consumption kinetics of acetogens are required to assess their potential in biotechnological processes. In this study, initial H consumption rates at a range of different initial H concentrations were measured for three different acetogens.
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