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Swinging Pendulum Between Risks and Benefits of Antiplatelet Agents: A Call for Consistency in the Interpretation of Evidence and Guideline Recommendations.
Circulation
January 2025
Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland (A.L., M.V.).
Can Medical Licensing Boards Swing the Pendulum Towards Judicious Opioid Prescribing Practices?
J Law Med Ethics
December 2024
UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PENNSYLVANIA, USA.
In the initial wave of the opioid crisis, uninformed prescribing practices and lax oversight were the drivers of opioid addiction and death. Although opioid prescriptions have decreased by 44.4 percent between 2011-2020, the number of deaths linked to prescription opioids has decreased only marginally.
View Article and Find Full Text PDFSwinging of the Pendulum: Should We Pursue Surgical Management Over Minimally Invasive Management of Atrial Fibrillation?
J Cardiothorac Vasc Anesth
November 2024
Department of Anesthesia and Critical Care Medicine, University of Chicago, Chicago, IL.
Optimization of and experimentation with a bifurcated swing tube strip fertilizer spreading device based on MBD-DEM coupling.
Front Plant Sci
October 2024
College of Mechanical and Electrical Engineering, Northeast Forestry University, Harbin, China.
Introduction: To improve the utilization rate of fertilizers, realize the precise spreading of fertilizers in controllable strips, and ensure the uniformity of fertilizer spreading in both longitudinal and transversal directions, a bifurcated swing tube fertilizer spreading device driven by a spatial hammer pendulum crank mechanism was designed.
Methods: First, the drive mechanism was designed based on the cylindrical pair of the mechanism. A mathematical model pendulum equation was used to design the swing tube, and the equation of motion of fertilizer particles was established by analyzing the motion and force of fertilizer particles in fertilizer spreading.
Hyperfunctional T cell responses unchecked by regulatory T cells are unable to resolve hepaciviral infection without humoral contribution.
J Hepatol
October 2024
Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address:
Background & Aims: The most recent T cell-based vaccine against HCV tested in humans failed to swing the pendulum from chronicity to resolution, despite eliciting cellular responses in most individuals. These results naturally evoke the question of whether hyperactivated responses of a single adaptive immune arm are capable of inducing HCV clearance or if coordinated efforts between antibodies and T cells are indeed necessary. Here, we sought to address this point in determining whether the suppression of antiviral T cell and IgG responses by regulatory T cells (Tregs) is a critical prerequisite of delayed viral clearance or overt chronicity.
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